Firstly, cancer transformation is not the main complication of chronic obstructive pulmonary disease (COPD), but both COPD and lung cancer share a common cause, which is smoking. Therefore, COPD and lung cancer are generally considered two different diseases, and the symptoms of COPD combined with lung cancer are mainly those of lung cancer, typically including irritating dry cough, blood-streaked sputum, weight loss, etc. Thus, lung imaging studies can be used to preliminarily determine the possibility of cancer in patients, and further diagnostic steps can be chosen based on the patient’s imaging and related symptoms, including biopsy, bronchoscopy, etc.