The difference between Mycoplasma pneumonia and Chlamydia pneumonia

Written by Han Shun Li

Pulmonology

Updated on March 28, 2025

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Mycoplasma pneumonia and Chlamydia pneumonia are clinically similar, making them difficult to distinguish from each other as both have similar symptoms and treatment options. Treatments such as erythromycin and quinolones can be used for both. The main difference between them lies in the laboratory tests. If tests for pneumonia, Mycoplasma antibodies or antigens are positive, then it is diagnosed as Mycoplasma pneumonia. If tests for Chlamydia pneumonia antibodies are positive, or if a throat swab test detects Chlamydia, then it is diagnosed as Chlamydia pneumonia.

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Children presenting with pneumonia primarily exhibit symptoms related to respiratory infections, with fever often as a typical manifestation. Common symptoms include sudden chills, high fever, fatigue, headache, nausea, and vomiting, followed by an irritative dry cough. As the condition progresses, the dry cough turns into a productive cough with phlegm, accompanied by difficulty breathing, chest pain, and expectoration. Some may also show signs of oxygen deprivation such as cyanosis of the lips and changes in nail color. Active chest X-ray and routine blood tests are necessary for diagnosis.

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The pneumonia vaccine is primarily aimed at preventing pneumonia caused by Streptococcus pneumoniae infection. Streptococcus pneumoniae is the most significant and common bacterium causing pneumonia worldwide. This bacterium is also the most common cause of community-acquired pneumonia in children and is the main pathogen causing otitis media, meningitis, and bacteremia in children. Currently, there are two types of pneumonia vaccines available in China: the 23-valent polysaccharide vaccine, which is suitable for people over two years old, and the 7-valent vaccine, which is suitable for infants under two years old. According to the regulations on vaccine distribution and vaccination management implemented in our country, vaccines are clearly divided into two categories: the first category includes vaccines provided free by the government to citizens, who are required to be vaccinated according to government regulations; the second category includes other vaccines that are paid for and voluntarily received by citizens. The pneumonia vaccine belongs to the second category, which is a self-funded vaccine.

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What department does pneumonia go to?

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How to completely cure pneumonia in children?

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"Does a weakly positive Mycoplasma pneumoniae indicate pneumonia?"

During the testing process, if Mycoplasma pneumoniae shows a weakly positive result, this does not necessarily indicate that the person has pneumonia. A weakly positive result for Mycoplasma pneumoniae only suggests a possible infection, but does not confirm pneumonia. If there is a suspicion, further investigation, such as chest radiography, should be conducted. If chest radiography reveals changes in lung patterns or patchy areas in the lungs, then it can be considered that the person may have Mycoplasma pneumoniae pneumonia. If the chest radiography is normal, it cannot be concluded that the person has pneumonia.