The symptoms of rabies can include fever, general discomfort, muscle soreness, fatigue, and headaches, which are typical preclinical symptoms. Subsequently, numbness, pain, and itching at the site of the bite may occur. This is followed by a series of related neurological symptoms, such as hydrophobia and aerophobia, where even the sight or mention of water can trigger involuntary spasms in the throat muscles and difficulty swallowing. There is also extreme sensitivity and fear of bright lights and noises, agitation, eventually leading to coma and death.