Firstly, rheumatoid arthritis is often related to infections, with streptococcal infection being the most common. Some individuals have strong resistance and do not show many clinical symptoms, only presenting signs similar to those of a cold, such as a runny nose and sore throat. These symptoms can generally be relieved on their own after rest and increased water intake.

For those with low immunity or immune dysfunction, the occurrence of streptococcal infection often leads to fever, joint pain, and valvular heart disease. Treatment at this stage requires the use of long-acting antibiotics to control the condition. Treatment during the acute phase generally lasts about a month. If the heart is involved and valvular disease occurs, there are often some residual sequelae.