What does early lupus erythematosus look like?

Written by Liu Li Ning
Rheumatology
Updated on May 05, 2025
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In the early stages of lupus erythematosus, symptoms such as fever, rash, joint pain, oral ulcers, and hair loss may occur. Lupus erythematosus is a heterogeneous disease that can present a variety of clinical symptoms. This disease can affect multiple systems and organs throughout the body, leading to different clinical manifestations depending on the target organ involved. For example, patients with pulmonary interstitial fibrosis may experience chest tightness, shortness of breath, and difficulty breathing; if the heart is affected, significant pericardial effusion may occur, possibly leading to difficulty breathing. The specific pathogenesis of systemic lupus erythematosus is still unclear. It is more commonly seen in females. Therefore, there is currently no specific cure for systemic lupus erythematosus, and the treatment mainly involves long-term maintenance with corticosteroids and immunosuppressants.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What should I do if I have a fever with lupus erythematosus?

When patients with lupus experience fever, the fundamental approach is the use of ample steroids or other immunosuppressive drugs for treatment, which generally can quickly normalize body temperature. However, some patients may also experience fever during steroid use, possibly due to the steroids reducing immune function and inducing a bacterial infection. At this point, it is necessary to find evidence of infection and promptly treat with adequate sensitive antibiotics. Then, there will certainly be questions about why patients with lupus who have a fever cannot use antibacterial drugs or antipyretics. This is because fever in lupus patients is often an important indicator of disease activity. During acute phases, the fever is typically high, not caused by external infections, thus antibacterial drugs are ineffective. Using antipyretics can temporarily normalize body temperature, but once the effect of the medication wears off, the high fever may recur. Patients with lupus should not casually use medications. If medication is needed, it should be used under the guidance of a doctor.

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Written by Liu Li Ning
Rheumatology
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What happens if someone with lupus occasionally drinks alcohol?

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems and organs throughout the body and is more commonly seen in women, particularly during their childbearing years. Clinically, it is mainly characterized by fever, rash, joint pain, oral ulcers, and hair loss. In terms of diet, it is recommended to eat light and avoid spicy and irritating foods. It is crucial to strictly abstain from smoking and drinking, avoid excessive fatigue, and direct sun exposure. Importantly, patients should strictly follow medical advice regarding medication and have regular check-ups.

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Written by Liu Li Ning
Rheumatology
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Systemic lupus erythematosus has several symptoms, including:

Common manifestations of lupus include facial butterfly rash, discoid rash, photosensitivity, joint pain or arthritis, mental symptoms, recurrent oral ulcers, hair loss, foamy urine, etc. Patients with mesenteric vasculitis as the initial symptom mainly complain of abdominal pain and bloating. If the hematological system is the initial symptom, the main complaint is usually fatigue. If the patient presents with a seizure as the initial symptom, the main manifestation is limb convulsions. The heterogeneity of lupus is strong, and different patients can exhibit completely different clinical manifestations.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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Lupus is what disease?

Lupus erythematosus, also known as systemic lupus erythematosus, is a chronic autoimmune disease involving multiple systems and organs. Patients' serum contains various autoantibodies, with the main pathological changes being inflammatory reactions and vascular abnormalities. Most patients exhibit butterfly-shaped erythema on the bridge of the nose and cheeks, which is the most characteristic manifestation of lupus erythematosus. The clinical presentations of systemic lupus erythematosus are diverse, generally characterized by the "four multiples": involvement of multiple systems, multiple organs, multiple autoantibodies, and a higher prevalence among women of childbearing age. Without proper and effective treatment, the mortality rate is high, with the main causes of death being infections, renal failure, and damage to the central nervous system.

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Written by Liu Li Ning
Rheumatology
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What is lupus and is it serious?

Lupus erythematosus is an autoimmune disease, which can be very severe in some cases and mild in others. For example, cutaneous lupus erythematosus generally does not involve major organs and usually presents with mild symptoms, primarily affecting the skin and mucous membranes. However, systemic lupus erythematosus can affect significant organs like the kidneys and heart in many patients, often leading to severe medical conditions. Especially, patients with rapidly progressive glomerulonephritis and those with coronary atherosclerotic heart disease tend to have a higher mortality rate. If systemic lupus erythematosus is diagnosed, it is crucial to receive standardized treatment early. Typically, treatment involves long-term maintenance with corticosteroids and immunosuppressants to control the progression of the disease and reduce the likelihood of mortality.