What does early lupus erythematosus look like?

Written by Liu Li Ning
Rheumatology
Updated on May 05, 2025
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In the early stages of lupus erythematosus, symptoms such as fever, rash, joint pain, oral ulcers, and hair loss may occur. Lupus erythematosus is a heterogeneous disease that can present a variety of clinical symptoms. This disease can affect multiple systems and organs throughout the body, leading to different clinical manifestations depending on the target organ involved. For example, patients with pulmonary interstitial fibrosis may experience chest tightness, shortness of breath, and difficulty breathing; if the heart is affected, significant pericardial effusion may occur, possibly leading to difficulty breathing. The specific pathogenesis of systemic lupus erythematosus is still unclear. It is more commonly seen in females. Therefore, there is currently no specific cure for systemic lupus erythematosus, and the treatment mainly involves long-term maintenance with corticosteroids and immunosuppressants.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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Lupus is what disease?

Lupus erythematosus, also known as systemic lupus erythematosus, is a chronic autoimmune disease involving multiple systems and organs. Patients' serum contains various autoantibodies, with the main pathological changes being inflammatory reactions and vascular abnormalities. Most patients exhibit butterfly-shaped erythema on the bridge of the nose and cheeks, which is the most characteristic manifestation of lupus erythematosus. The clinical presentations of systemic lupus erythematosus are diverse, generally characterized by the "four multiples": involvement of multiple systems, multiple organs, multiple autoantibodies, and a higher prevalence among women of childbearing age. Without proper and effective treatment, the mortality rate is high, with the main causes of death being infections, renal failure, and damage to the central nervous system.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What are the symptoms of a lupus flare-up?

After treatment with steroids and other therapies, active lupus erythematosus usually improves and enters a stable phase. However, factors such as infection, pregnancy, surgery, fatigue, and discontinuation of medication can trigger the transition from a stable phase back to an active phase of lupus erythematosus. The following symptoms should be considered for a possible recurrence of the disease: First, onset of fever without reasons related to colds or infections. Second, appearance of new rashes or vascular-like rashes on fingertips and other areas. Third, recurrence of joint swelling and pain. Fourth, significant hair loss. Fifth, development of fresh ulcers in the mouth or nose. Sixth, development of fluid accumulation in the chest cavity or pericardium. Seventh, increased protein in urine, decrease in white blood cells or platelets, or significant anemia.

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Written by Liu Li Ning
Rheumatology
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What happens if someone with lupus occasionally drinks alcohol?

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems and organs throughout the body and is more commonly seen in women, particularly during their childbearing years. Clinically, it is mainly characterized by fever, rash, joint pain, oral ulcers, and hair loss. In terms of diet, it is recommended to eat light and avoid spicy and irritating foods. It is crucial to strictly abstain from smoking and drinking, avoid excessive fatigue, and direct sun exposure. Importantly, patients should strictly follow medical advice regarding medication and have regular check-ups.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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Is lupus contagious?

Lupus erythematosus is not contagious. The occurrence of lupus erythematosus is related to genetic factors, the levels of sex hormones in the body, and certain environmental factors that the body is exposed to. It is the combined effect of these factors that lowers the body's immune tolerance, causing disorder in immune function, and thus leading to this autoimmune disease. Therefore, unlike diseases caused by various pathogens, it cannot be transmitted from person to person. When normal individuals come into contact with patients, there is no need to fear contagion or to isolate the patients. During the remission and stable phases of the disease, lupus patients can engage in regular work, study, and participate in social activities just like healthy individuals.

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Written by Liu Li Ning
Rheumatology
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What should I do about lupus erythematosus?

Lupus erythematosus requires early and formal treatment to stabilize the condition. For mild cutaneous lupus erythematosus, topical immunosuppressants, such as tacrolimus ointment, and immunomodulators, such as hydroxychloroquine, can be used. Low-dose corticosteroids may be necessary for combination therapy. Systemic lupus erythematosus generally requires corticosteroids as the basis of treatment, combined with one or several immunosuppressants to effectively control the disease. Systemic lupus erythematosus often involves multiple organs, with the kidneys, hematological system, and lungs being the most common. Therefore, it is necessary to use corticosteroids in combination with immunosuppressants to control the progression of the disease, as using only immunomodulators is often insufficient.