Male patients with systemic lupus erythematosus may initially exhibit mild symptoms such as general fatigue, fever, joint swelling and pain, facial erythema, as well as oral ulcers, hair loss, dry mouth, and dry eyes. As the disease progresses, some patients may experience involvement of vital internal organs. Common manifestations include interstitial lung disease, characterized primarily by chest tightness and asthma after activity. The earliest and most frequently affected system in male systemic lupus erythematosus is the renal system, showing symptoms like edema and significant proteinuria. Severe cases may also develop lupus cerebritis.