Patients with polycystic kidney disease who develop kidney stones should be treated the same as patients without polycystic kidney disease. It is encouraged for patients to drink more water. If the stones are symptomatic, treatments such as extracorporeal shock wave lithotripsy or percutaneous nephrolithotomy may be considered. The main principles of treatment include managing renal colic, promoting stone expulsion, dissolving stones, or surgical interventions, as well as preventing recurrence. During a renal colic episode, it is primarily recommended to administer antispasmodic analgesics. Commonly used medications include scopolamine butylbromide and atropine, or combinations of atropine with pethidine or morphine. Expulsion therapy mainly involves drinking plenty of water, proper physical activity, and the use of some antispasmodic drugs to help expel the stones. Surgical treatment is aimed at patients with anuria and post-renal acute renal failure, or in cases where the stone diameter is larger than one centimeter, or if the expulsion therapy is ineffective, especially if there are still episodes of renal colic. Systemic metabolic disorders are an important cause of kidney stone formation, thus even after stones are cleared, recurrence is possible. Therefore, to prevent recurrence, it is advisable to ensure a daily urine output of 2000 to 2500 milliliters, avoid drinking tea and coffee as much as possible, adjust dietary habits, and treat systemic metabolic abnormalities, such as hypercalcemia, hyperuricemia, and cystinuria, among others.