What causes ovarian cancer?

Written by Liu Liang

Oncology

Updated on March 29, 2025

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The causes of ovarian cancer, and its mechanism of onset, are not yet very clear. Some risk factors that have been relatively well established in relation to the occurrence of ovarian cancer include early menarche, which means starting menstruation at an earlier age, late menopause, and not having a history of pregnancy; these conditions are some of the risk factors for ovarian cancer. Additionally, the occurrence of ovarian cancer is also somewhat related to familial or genetic factors.

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Written by Zhou Chen

Oncology

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How is ovarian cancer diagnosed?

Early screening for ovarian cancer allows for about 20% of cases to be diagnosed in their early stages. Detection generally follows these procedures: 1. Routine gynecological health check-ups. 2. Visiting a hospital due to certain symptoms. 3. Ovarian cancer screening. Common methods include transvaginal ultrasound and serum CA125 testing. Additional tests include tumor marker CA125 and checks for AFP, CA19-9, and CEA. Ultrasonography (B-ultrasound) can preliminarily determine the tumor size, shape, solidity, location, and its relation to surrounding organs. CT scans and MRI can further clarify the tumor's nature and the extent of invasion into the abdominal and pelvic organs. If necessary, gastroscopy can be performed to rule out primary gastrointestinal tumors, and if economic conditions allow, a PADCT scan can also be conducted.

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Oncology

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Does ovarian cancer hyperthermic intraperitoneal chemotherapy work?

Patients with ovarian cancer are prone to peritoneal metastasis, so many patients develop ascites during the discovery of the disease or its progression. A large amount of ascites is a common concurrent symptom in patients with ovarian cancer. For patients with significant ascites like this, hyperthermic intraperitoneal chemotherapy (HIPEC) can be performed, which involves infusing chemotherapy drugs into the abdominal cavity and then combining it with thermotherapy. This treatment generally has a decent effect, especially in controlling the spread of cancer cells in the peritoneum and managing ascites.

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Written by Liu Liang

Oncology

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Is ovarian cancer prone to metastasis?

Ovarian cancer relatively tends to metastasize more easily, and clinically, it is often found at a later stage in most patients. The main pathway of metastasis of ovarian cancer is implantation metastasis, where the tumor can breach the capsule and extensively implant in the pelvic or abdominal cavity. Another pathway is local spread, where it can spread to the uterus, fallopian tubes, and other tissues within the pelvic cavity. Additionally, ovarian cancer can also spread to distant organs throughout the body via the lymphatic system or through hematogenous dissemination.

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Written by Gong Chun

Oncology

50sec

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How is ovarian cancer treated?

Our treatment principle is that once an ovarian tumor is detected, surgical treatment should be performed. First and foremost, we need to confirm the diagnosis. Second, we should clarify the pathological staging of the ovarian cancer to guide the treatment. It's not a single approach; it's a comprehensive treatment plan. For example, if it is early stage and there are no surgical contraindications, we can proceed with surgical treatment. After the surgery, we can provide adjunctive chemotherapy. If surgery is not immediately feasible, we can also provide neoadjuvant therapy to reduce the stage before proceeding with ovarian cancer surgery. Moreover, there is now targeted therapy and immunotherapy for ovarian cancer, so it is a comprehensive treatment plan.

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Written by Yan Chun

Oncology

1min 10sec

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Early symptoms of ovarian cancer

The early clinical symptoms of ovarian cancer primarily include the following aspects: 1. Discomfort and dull pain in the lower abdomen, with some patients experiencing a sensation of heaviness in the pelvis. Alongside this, patients may also experience poor appetite, nausea, belching, and a feeling of bloating in the stomach. 2. A sensation of abdominal fullness is a clinical manifestation that can appear early in ovarian cancer patients, often caused by cancerous ascites due to the disease. 3. In very few cases, early-stage ovarian cancer patients may feel a mass in the abdomen, typically in leaner patients. 4. Some early-stage patients may experience mild abdominal pain, which generally occurs intermittently and can resolve on its own without the need for medication. 5. Patients may exhibit menstrual irregularities and some endocrine symptoms, such as vaginal bleeding.