The treatment of bone metastases from prostate cancer can include first-line hormonal therapy. During hormonal treatment, bisphosphonates can be used in conjunction to increase bone density. Additionally, external radiation therapy can improve localized bone pain. Patients with multiple bone metastases or bone pain can undergo radionuclide therapy. Another method is the use of analgesic drug therapy, which is also a main approach to alleviate pain from bone metastases of prostate cancer.