What is the likelihood of metastasis for colon cancer with a certain Ki-67 index?

Written by Cui Fang Bo

Oncology

Updated on March 21, 2025

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Currently, the Ki67 index in colon cancer cannot be used as a predictive factor for metastasis. Ki67 reflects the proliferation index of the tumor and is related to the malignancy level of the tumor, but it is not possible to judge the risk of subsequent metastasis based on the Ki67 value.

The factors that can be used to assess the risk of postoperative metastasis in colon cancer mainly include the depth of local invasion of the colon cancer, whether there is lymph node metastasis, and the presence of certain specific gene mutations. The deeper the invasion, the higher the risk of metastasis. Patients with lymph node metastasis have a higher risk of distant recurrence and metastasis compared to those without detected lymph node metastasis.

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In clinical practice, for patients with mid-to-late-stage colon cancer, even after curative surgical resection, it is often difficult to completely remove the tumor. This is because by the mid-to-late stages, the colon cancer has typically started to invade surrounding tissues. Despite curative surgery, patients may still have subclinical lesions, which are typically hard to detect either under a microscope or with the naked eye. The presence of these subclinical lesions leads to a higher likelihood of recurrence and metastasis after curative surgery in mid-to-late-stage colon cancer patients. Therefore, to reduce the rates of recurrence and metastasis, it is common clinical practice to administer adjuvant chemotherapy and radiotherapy after the curative surgical resection for patients with mid-to-late-stage colon cancer, aiming to decrease the risk of cancer recurrence and metastasis.

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Colorectal cancer is a malignant tumor of the digestive system, and its occurrence is related to the following factors: First, dietary factors. A high-fat content and a low fiber content in the diet both lead to an increased incidence of colorectal cancer. Furthermore, long-term consumption of pickled foods can also increase the incidence of colorectal cancer, presumably because these foods contain higher levels of nitrosamine carcinogens. Second, some benign chronic diseases of the colon, such as adenomatous polyps and certain chronic colitis, can also lead to an increased incidence of colorectal cancer. Third, environmental factors. Epidemiological studies have found that the occurrence of colorectal cancer is related to geographical distribution. In some environments with a high incidence of colorectal cancer, the content of some trace elements in the soil is too low, leading to a high incidence of colorectal cancer.

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What is the likelihood of metastasis for colon cancer with a certain Ki-67 index?

Currently, the Ki67 index in colon cancer cannot be used as a predictive factor for metastasis. Ki67 reflects the proliferation index of the tumor and is related to the malignancy level of the tumor, but it is not possible to judge the risk of subsequent metastasis based on the Ki67 value. The factors that can be used to assess the risk of postoperative metastasis in colon cancer mainly include the depth of local invasion of the colon cancer, whether there is lymph node metastasis, and the presence of certain specific gene mutations. The deeper the invasion, the higher the risk of metastasis. Patients with lymph node metastasis have a higher risk of distant recurrence and metastasis compared to those without detected lymph node metastasis.

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