In clinical practice, for patients with mid-to-late-stage colon cancer, even after curative surgical resection, it is often difficult to completely remove the tumor. This is because by the mid-to-late stages, the colon cancer has typically started to invade surrounding tissues. Despite curative surgery, patients may still have subclinical lesions, which are typically hard to detect either under a microscope or with the naked eye. The presence of these subclinical lesions leads to a higher likelihood of recurrence and metastasis after curative surgery in mid-to-late-stage colon cancer patients. Therefore, to reduce the rates of recurrence and metastasis, it is common clinical practice to administer adjuvant chemotherapy and radiotherapy after the curative surgical resection for patients with mid-to-late-stage colon cancer, aiming to decrease the risk of cancer recurrence and metastasis.