What are the symptoms of subungual melanoma?

Written by Yan Chun
Oncology
Updated on December 31, 2024
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Subungual melanoma, clinically, displays different symptoms depending on the stage. In its early stages, subungual melanoma primarily manifests as changes in nail color, with some cases showing localized thickening of the nail. As the melanoma progresses, abnormal secretions such as bloody or serous fluids may appear under the nail, and the nail itself may become uneven. As the subungual melanoma invades surrounding tissues, symptoms such as swelling, pain, or bleeding in the localized fingernail may occur. In advanced stages, symptoms of metastatic sites, such as coughing, chest pain, and chest tightness from lung metastases, can also manifest.

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Stage IV melanoma is what stage?

Melanoma stage IV is stage 4, where IV is the Roman numeral for 4. Stage IV melanoma means that the melanoma is no longer confined to the site of origin and has metastasized to distant organs. Melanoma commonly originates in the skin and mucous membranes, with the most common sites of metastasis being the lymph nodes and lungs. Once melanoma reaches stage 4, the opportunity for curative surgery is lost. Treatment primarily involves immunotherapy, targeted molecular therapy, etc., and is incurable.

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What should be done about melanoma brain metastasis?

After melanoma metastasizes to the brain, it requires early treatment, which mainly includes the following measures: First, general supportive care, such as using mannitol or glycerol fructose to reduce intracranial pressure and alleviate symptoms like headache, nausea, and vomiting if increased intracranial pressure occurs after brain metastasis; Second, local treatment, such as whole brain radiotherapy or precise Gamma Knife surgery, to control the intracranial lesion after brain metastasis; Third, systemic treatment, as melanoma with brain metastases indicates stage IV disease, requiring control of the condition through systemic treatments including chemotherapy, targeted drug therapy, and immunotherapy.

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Melanoma originates from which tissue?

Melanoma does not originate from any specific tissue, but from melanocytes. Therefore, melanoma can occur in any tissue where melanocytes are present. The most common sites for melanoma are the skin and mucous membranes. Additionally, because melanocytes are widely present throughout the body, melanoma can also occur in hollow organs such as the gastrointestinal tract, in skeletal muscles, and in the nervous system. Once diagnosed, melanoma needs to be treated promptly. The main treatments include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.

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What is melanoma?

Melanoma, also known as malignant melanoma, originates from the malignant transformation of melanocytes. It is commonly found in individuals with fair skin, blond or red hair, and blue eyes, who are often prone to this type of disease, particularly in tropical regions where the condition is more prevalent. The incidence rate increases after the age of fifty, and the rate of occurrence between men and women within the same group is quite similar. In a minority of cases, melanoma can also occur in parts outside of the skin, such as the anus, rectum, esophagus, or inside the eyes. When the tumor is confined within the epidermis, referred to as in situ carcinoma, it can be cured through surgery. If there is metastasis, treatment may include immunotherapy, chemotherapy, or local radiotherapy.

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How to distinguish whether melanoma is benign or cancerous

Melanomas are always malignant; there are no benign melanomas. Benign lesions are called pigmented nevi, which are usually classified into three types: intradermal nevi, junctional nevi, and compound nevi. When a pigmented nevus becomes malignant, it is then referred to as melanoma. Therefore, in clinical practice, when we mention melanoma, we are referring to malignant melanoma. Malignant melanoma is staged based on the degree of invasion and whether it has metastasized. Treatment methods vary depending on the stage, and there are differences in treatment approaches. Therefore, if a pigmented nevus visibly enlarges over a short period, and shows symptoms such as ulceration, bleeding, or pain, it is necessary to promptly visit a reputable hospital's dermatology department for surgical removal, followed by a pathological examination.