Can osteosarcoma be cured?

Written by Guan Yu Hua
Orthopedic Surgery
Updated on January 16, 2025
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Osteosarcoma is a malignant tumor of the bone, commonly occurring in adolescents and young adults, primarily near the proximal end of the tibia, the distal ancient end, or near the proximal end of the humerus, most frequently seen at the end of the bone shaft. In the early stages, there are no symptoms, and once detected, it is usually in the middle to late stages. An X-ray examination can be used for diagnosis, often showing a Codman's triangle or a sunburst pattern. Osteosarcoma generally needs early detection and treatment. If a primary lesion is present, surgical treatment can be pursued, including procedures such as resection with inactivation and reimplantation or limb-sparing surgery with a prosthesis. Another option is amputation, followed by extensive chemotherapy. The likelihood of osteosarcoma spreading to the lungs is very high. In recent years, with early diagnostic physical examinations and the rapid development of chemotherapy, the five-year survival rate for osteosarcoma can reach 50%.

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Written by Na Hong Wei
Orthopedics
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Postoperative recurrence symptoms of osteosarcoma

Symptoms of recurrent osteosarcoma after surgery are generally consistent with the symptoms before the initial surgery. The main symptoms include: Firstly, localized pain, which is persistent, progressive, and does not alleviate, including pain that worsens at night. Secondly, localized swelling, which usually occurs around the surgical site if limb-sparing surgery was performed, or at the stump if amputation was done. Thirdly, the appearance of systemic cachexia and symptoms of metastasis. Systemic cachexia typically includes weight loss, anemia, fatigue, and loss of appetite. For osteosarcoma, metastasis primarily targets the lungs, where numerous cancerous shadows can be detected. Thus, the main recurrent symptoms of osteosarcoma after surgery include pain, swelling, and cachexia.

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Written by Cheng Bin
Orthopedics
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Can osteosarcoma be detected on an X-ray?

First of all, it should be noted that osteosarcoma can be detected in patients through imaging tests. For example, a localized MRI can clearly diagnose osteosarcoma. Once detected, it is necessary to actively pursue symptomatic treatment. Surgical removal is usually the main treatment method, involving the excision of the affected area. If necessary, the excision may need to be extended, or amputation may be required. After surgery, the excised specimen should be sent for pathological examination. Based on the results of the pathology test, further radiation therapy or chemotherapy can be completely sufficient. The results are generally quite good for most patients.

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Written by Wang Cheng Lin
Orthopedics
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How long is the latent period of osteosarcoma?

In clinical practice, there is no such thing as a latency period for malignant bone tumors, because these tumors progress very quickly. So, if you experience symptoms such as swelling and pain in the affected limb, if you can feel a mass, and if the pain severely impacts your daily life, you should promptly go to a hospital to get an imaging test done to determine whether a bone tumor is present. Only through imaging and accurate diagnosis can early diagnosis and treatment be achieved, which is the best treatment approach for osteosarcoma. Therefore, in clinical practice, there is no concept of a latency period for malignant bone tumors.

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Written by Wang Cheng Lin
Orthopedics
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Does osteosarcoma require amputation?

Do osteosarcomas require amputation? In the past, the likelihood of amputation for treating osteosarcoma was very high. However, currently, the rate of amputation is very low, and the limb-salvage rate is very high. This is due to a new chemotherapy protocol in medical practice, which involves initial chemotherapy followed by surgery, and then continued chemotherapy post-operatively. The limb-salvage rate with this treatment plan can reach about 75% to 80%. Therefore, currently, most osteosarcoma patients do not require amputation. Unlike the past, where amputation rates were very high, today's medical approach is very advanced, generally resulting in a very high rate of limb preservation for osteosarcoma patients.

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Written by Wang Cheng Lin
Orthopedics
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Characteristics of bone metastasis in osteosarcoma

Osteosarcoma, when it metastasizes to the bone, is very complex to treat. Surgery cannot fully excise the metastasized bone tissue. Currently, clinical treatments mainly involve a comprehensive approach using radiotherapy, chemotherapy, and traditional Chinese medicine. Most osteosarcomas show improvement in symptoms and an increase in patients' quality of life after radiotherapy and chemotherapy treatment. However, these treatments have their complications. For instance, while killing tumor cells, they can also damage normal cells, resulting in a decreased immune response and various related complications. Ultimately, this might lead to the cessation of radiotherapy and chemotherapy treatments. Therefore, current treatments for bone metastases from osteosarcoma involve using radiotherapy and chemotherapy in conjunction with traditional Chinese medicine. Traditional Chinese medicine may enhance the efficacy of radiotherapy and chemotherapy while also reducing their toxicity. (The use of medications should be under the guidance of a professional doctor.)