The difference between sarcoma and osteosarcoma

Written by Peng Li Bo

Oncology

Updated on September 25, 2024

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The relationship between sarcoma and osteosarcoma is very simple; it is a relationship of containment where sarcoma includes osteosarcoma. Simply put, the concept of sarcoma is broader, and osteosarcoma is a subtype under it. Sarcoma itself also includes malignant tumors occurring in blood vessels, fat, nerves, and muscles, such as angiosarcoma, liposarcoma, rhabdomyosarcoma, and leiomyosarcoma, and, of course, osteosarcoma. However, both sarcoma and osteosarcoma are malignant tumors, and it's important to clarify this concept. Moreover, osteosarcoma is more common in young people.

Other Voices

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Written by Guan Yu Hua

Orthopedic Surgery

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Is a fracture in osteosarcoma very dangerous?

Osteosarcoma is a malignant tumor of the bone, commonly found in adolescents and young adults, primarily occurring near the proximal tibia, distal femur, and proximal humerus, mostly at the metaphyseal ends. The tumor itself can lead to bone destruction and periosteal reactions. Pathological fractures may occur, which are frequently observed clinically. If a fracture occurs, radiographic examination can generally detect it, often showing a Codman's triangle or sunburst pattern. Early detection and treatment are crucial. Once a pathological fracture is observed, it typically indicates a middle to late stage of the disease, with a particularly high likelihood of lung metastasis. The situation with just a pathological fracture is quite severe, and unlike other fractures that might be managed with steel plates or intramedullary pins, treatment here is conservative, possibly requiring amputation, though limb-sparing approaches may also be necessary. Detecting the condition early, before distant metastasis, and combining treatment with radiotherapy or chemotherapy, can result in a five-year survival rate above 50%. The threat posed by pathological fractures alone is significant, and amputation may be necessary, with chemotherapy likely required post-surgery.

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Written by Na Hong Wei

Orthopedics

1min 8sec

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Is there a cure for bone metastasis of osteosarcoma?

Is there any hope for osteosarcoma bone metastasis? If osteosarcoma develops bone metastasis, there is still hope for treatment. However, once metastasis occurs, the treatment costs, difficulty, and prognosis tend to be relatively unfavorable. Additionally, osteosarcoma itself invades and damages the bone. As the disease progresses, it stimulates osteogenesis which eventually leads to both bone formation and damage. Generally, the appearance of osteogenic changes often indicates a shift towards a better prognosis for the bone. Therefore, if osteosarcoma has metastasized, while treating the primary lesion of the tumor, it is also crucial to actively treat the metastatic sites. Thus, the difficulty of the treatment and the prognosis might not be very optimistic, but it certainly hasn't reached a point where the disease is untreatable. Therefore, once osteosarcoma metastasizes, it is recommended to visit the oncology department of a reputable hospital for systematic treatment by a doctor.

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Written by Wang Cheng Lin

Orthopedics

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Osteosarcoma common onset age

Osteosarcoma most commonly occurs in adolescents under the age of 20, or in children, and is a type of malignant tumor. It is the most common malignant bone tumor in children, accounting for about 5% of all malignant tumors in children, making this age group highly susceptible to osteosarcoma. The formation of osteosarcoma is mainly due to external factors such as viral infections and genetic mutations that lead to cell mutations. Osteosarcoma is a typical malignant tumor that destroys bone and surrounding soft tissue, leading to pathological fractures. It can also form distant metastases, thus posing a significant threat.

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Written by Guan Yu Hua

Orthopedic Surgery

1min 5sec

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How big do osteosarcomas generally grow?

The size of osteosarcoma is generally difficult to measure. By undergoing radiographic examination, Codman's triangle and bone destruction can be observed in the patient's images, which can be diagnosed as osteosarcoma. Further biopsy is then required. Osteosarcoma typically presents as a mass approximately the size of a fist, and early stages may involve malignant pulmonary metastasis. By conducting a pulmonary CT scan, lesions and metastatic foci can be discovered, primarily indicating bone destruction and the presence of Codman's triangle. Such destruction can deform the normal bone structure, and abnormal masses may be palpable during physical examinations, presenting in irregular shapes. This condition is commonly seen and cannot be evaluated merely by the size of the osteosarcoma. Early stages may involve lung metastasis, progressing to advanced stages where the prognosis is poor and survival rates significantly decrease. Therefore, this disease generally requires early diagnosis and treatment.

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What is osteosarcoma?

Osteosarcoma is a type of malignant tumor that occurs in the bones, generally classified as stage IIb. Common sites for osteosarcoma include the distal part of the bone, the proximal tibia, and the proximal humerus. It most commonly affects adolescents. Clinically, it primarily presents as persistent pain, including nighttime pain. Swelling and limited joint function typically occur around the common sites. Additionally, there are general symptoms associated with cachexia, such as malnutrition, anemia, mild or high fever, or weight loss. Fourthly, it is very prone to causing pathological fractures. Many osteosarcoma patients seek medical attention due to these fractures. Thus, osteosarcoma is a serious malignancy in the bones with a generally poor prognosis. Diagnosis and treatment of osteosarcoma are crucial; upon confirmation, timely treatment is necessary. The primary treatment approach is a combination therapy centered around surgery, typically involving preoperative chemotherapy, followed by surgical treatment and postoperative chemotherapy. Currently, the five-year survival rate for osteosarcoma has significantly improved, reaching approximately 70% to over 80%.