Is there any hope for osteosarcoma bone metastasis? If osteosarcoma develops bone metastasis, there is still hope for treatment. However, once metastasis occurs, the treatment costs, difficulty, and prognosis tend to be relatively unfavorable. Additionally, osteosarcoma itself invades and damages the bone. As the disease progresses, it stimulates osteogenesis which eventually leads to both bone formation and damage. Generally, the appearance of osteogenic changes often indicates a shift towards a better prognosis for the bone. Therefore, if osteosarcoma has metastasized, while treating the primary lesion of the tumor, it is also crucial to actively treat the metastatic sites. Thus, the difficulty of the treatment and the prognosis might not be very optimistic, but it certainly hasn't reached a point where the disease is untreatable. Therefore, once osteosarcoma metastasizes, it is recommended to visit the oncology department of a reputable hospital for systematic treatment by a doctor.