Why can't people with phenylketonuria eat vitamin C?

Written by Yan Xin Liang
Pediatrics
Updated on April 18, 2025
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Phenylketonuria is a common amino acid metabolic disorder. It primarily occurs because the patient's liver lacks phenylalanine hydroxylase, leading to the inability of phenylalanine to convert into tyrosine. This causes phenylalanine to accumulate in large amounts in the body, and it cannot be excreted through urine, presenting some corresponding clinical symptoms. The diet for phenylketonuria mainly involves avoiding high-protein foods, such as dairy, eggs, and soy products. Additionally, spicy, raw, and greasy foods should be avoided as they can negatively impact the health of the child. It is also beneficial to include starch-rich foods in the diet, such as potato starch, vermicelli, pumpkin, and Chinese yam, as these foods are low in phenylalanine and high in carbohydrates. Furthermore, vitamin C can be consumed without restrictions in cases of phenylketonuria, and it should be taken in moderation.

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Written by Yan Xin Liang
Pediatrics
1min 16sec home-news-image

Phenylketonuria is a disease.

Phenylketonuria is an autosomal recessive genetic disorder resulting from mutations in the phenylalanine hydroxylase gene, leading to reduced enzyme activity and the accumulation of phenylalanine and its metabolic products in the body, thereby causing this disease. Phenylketonuria is the most common congenital amino acid metabolic disorder, clinically characterized by intellectual developmental delays, light skin and hair pigmentation, and a mouse-like urine odor. The incidence of the disease varies by race and region, with an incidence rate in China of about 1 in 11,000. Phenylalanine is an essential amino acid for the human body, but due to reduced activity of phenylalanine hydroxylase, phenylalanine cannot be converted into tyrosine, leading to extremely high concentrations of phenylalanine in the blood, cerebrospinal fluid, and tissues. Abnormal metabolism produces a large amount of phenylpyruvic acid, phenylacetic acid, phenyllactic acid, and p-hydroxyphenylacetic acid, along with high concentrations of phenylalanine and its metabolic products, causing brain damage and corresponding symptoms.

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Written by Hu Qi Feng
Pediatrics
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How is phenylketonuria diagnosed?

Phenylketonuria screening is routinely conducted in China for all newborns. This involves pricking the heel to collect peripheral blood, which is then dropped on specialized filter paper and dried. The samples are sent to a screening laboratory for the measurement of phenylalanine concentration. If the concentration exceeds the threshold, further testing for phenylalanine is conducted. Normally, the concentration should be less than 120 micromoles per liter. Additionally, an analysis of the urinary purine profile can be performed.

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Written by Yan Xin Liang
Pediatrics
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How to diagnose phenylketonuria?

Phenylketonuria is a treatable hereditary metabolic disease, where our primary goal is early diagnosis and treatment. Currently, a universal newborn screening system has been widely implemented. The standard procedure requires that after three days of breastfeeding, peripheral blood is collected from the newborn's heel, dropped onto specialized blood collection filter paper, and, once dried, sent to a screening laboratory to measure the phenylalanine concentration. If the phenylalanine concentration exceeds the cutoff value, further differential diagnosis and confirmation are conducted. Treatment typically starts two to three weeks after birth, and the prognosis is good. Additionally, diagnostic tests for phenylketonuria include urine ferric chloride, 2,4-dinitrophenylhydrazine tests, urinary purine profile analysis, and tetrahydrobiopterin loading test. Another method is through DNA analysis.

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Written by Yan Xin Liang
Pediatrics
57sec home-news-image

Why can't people with phenylketonuria eat vitamin C?

Phenylketonuria is a common amino acid metabolic disorder. It primarily occurs because the patient's liver lacks phenylalanine hydroxylase, leading to the inability of phenylalanine to convert into tyrosine. This causes phenylalanine to accumulate in large amounts in the body, and it cannot be excreted through urine, presenting some corresponding clinical symptoms. The diet for phenylketonuria mainly involves avoiding high-protein foods, such as dairy, eggs, and soy products. Additionally, spicy, raw, and greasy foods should be avoided as they can negatively impact the health of the child. It is also beneficial to include starch-rich foods in the diet, such as potato starch, vermicelli, pumpkin, and Chinese yam, as these foods are low in phenylalanine and high in carbohydrates. Furthermore, vitamin C can be consumed without restrictions in cases of phenylketonuria, and it should be taken in moderation.

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home-news-image
Written by Yan Xin Liang
Pediatrics
1min 3sec home-news-image

Phenylketonuria positive means what?

Phenylketonuria is an autosomal recessive inherited disease and is the most common congenital amino acid metabolism disorder. Generally, if the activity of phenylalanine hydroxylase in the body is reduced, or if there is a deficiency in its coenzyme tetrahydrobiopterin, the concentration of phenylalanine in the blood and tissues will increase, and phenylpyruvic acid, phenylacetic acid, and phenyllactic acid in the urine will also increase. Generally, newborns may not show any special clinical features at first. Often, the first test results may be high due to maternal influence or dietary factors, which can cause these elevated indicators in newborns. If the second test is normal, there usually isn’t a significant problem. A third test can also be performed; if the third test still shows no issues, then phenylketonuria can be ruled out. Generally, if phenylketonuria is diagnosed, it should be treated promptly and properly.