To determine if it is syphilis rash, one can usually judge by the symptoms. The appearance of syphilis rash lacks obvious distinctive features, typically manifesting as red macules and papules all over the body, some might be patches. There are nodules on the skin, pustules, and some might also develop ulcers. After the appearance of syphilis rash, it generally does not cause intense itching and manifests symmetrical copper-red papules in the palms and soles of the feet, which is typically seen in secondary syphilis. If there has been unprotected sexual activity and these rashes appear on the limbs and trunk, it is necessary to visit a dermatology department in a standard hospital for specific examination. Many skin diseases have similar symptoms, and it is usually difficult to diagnose based solely on the appearance of the lesions.