What are the early symptoms of syphilis?

Written by Zhang Jian Bo
Dermatology
Updated on January 12, 2025
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Syphilis is divided into overt and latent syphilis. Latent syphilis, regardless of whether it is early or late stage, shows no symptoms at all and can only be confirmed by blood testing. The symptoms in the early stage are mainly those of overt syphilis, primarily manifestations of primary syphilis. The stages of primary, secondary, and tertiary syphilis begin with the appearance of a lesion at the site of infection, typically about 0.5 to 1 centimeter in diameter, with a hard, dark red nodule that feels like cartilage. The surface may have ulcers; it may be painless, or there may be no pain at all. Subsequently, nearby lymph nodes may become enlarged. This swelling of the lymph nodes is characterized by being painless, usually unilateral, with no redness or rupture. These are the clear symptoms of overt primary syphilis. If treated properly at this stage, recovery is generally rapid.

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Written by Luo Hong
Dermatology Department
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Syphilis IgM negative represents what?

Syphilis IgM negative, which is primarily screened using the ELISA method. Generally, a negative IgM can temporarily rule out syphilis. If still uncertain, further confirmatory syphilis tests can be conducted, such as TPPA (Treponema Pallidum Particle Agglutination) or TPHA (Treponema Pallidum Hemagglutination). Usually, syphilis can be temporarily dismissed if IgM is negative. However, if symptoms of a primary chancre are present, such as genital ulcers, an early Syphilis IgM might be negative. In such cases where symptoms are clear but IgM is negative, it is typically advised to retest after one month. If the result turns positive, a confirmatory test should be performed to diagnose and treat syphilis.

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Written by Zhu Zhu
Dermatology
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Does third-stage syphilis rash itch?

People with tertiary syphilis generally do not experience itching. Tertiary syphilis represents the later stages of the disease manifestation. Typically, the symptoms on the skin are neither painful nor itchy, which is the case for most individuals. However, some patients may feel differently from the majority, experiencing anomalies, or they might develop secondary conditions such as eczema or allergies, among others, possibly leading to mild itching and so on.

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Written by Zhu Zhu
Dermatology
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What is the typical titer for third-stage syphilis?

The titers of tertiary syphilis are generally lower than those of primary and secondary syphilis. Syphilis is divided into three stages. During the primary and secondary stages, the reactivity of the Treponema pallidum is higher, thus the titers are also higher. However, the titers for tertiary syphilis often appear lower or even negative. The level of syphilis titers is not significantly related to the duration of the illness. Interestingly, tertiary syphilis generally occurs when the disease has already progressed for more than two years, which results in lower titers.

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Written by Luo Hong
Dermatology Department
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Can syphilis antibodies be detected during the hard chancre stage?

During the hard chancre phase of syphilis, a portion of cases can test positive for Treponema pallidum, although some tests may return negative results. In such cases, it is advisable to retest after one month. The earliest detectable antibodies for Treponema pallidum are usually of two types: a Treponema pallidum-specific antibody, which appears earlier than the non-specific antibodies. There are tests for non-specific antibodies, commonly referred to as RPR or TRUST, which are standard practices in major hospitals. Therefore, in early-stage syphilis or primary syphilis with hard chancre, it is possible to find Treponema pallidum-specific antibodies positive, RPR or TRUST negative, or both negative. If syphilis is strongly suspected in such cases, a retest is recommended after one month.

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Written by Qu Jing
Dermatology
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How long is the latency period of syphilis?

Syphilis is a chronic infectious disease caused by the bacterium Treponema pallidum (TP), primarily transmitted through sexual contact and blood. The impact of syphilis is significant as it can affect all bodily tissues and organs, or can be transmitted through the placenta, leading to stillbirth, miscarriage, premature birth, and congenital infections. When syphilis is suspected, due to its complex clinical manifestations, a detailed medical history should be taken, a thorough physical examination conducted, and repeated laboratory tests performed to ensure an early and accurate diagnosis. It is important to trace back to any unprotected sexual contacts within the last six weeks and to routinely screen the sexual partners of patients for syphilis as well. Syphilis is divided into three stages: The diagnosis of primary syphilis is mainly based on the history of exposure, the incubation period (six weeks), typical clinical manifestations, and laboratory tests, noting that a negative syphilis serology result alone should not exclude the diagnosis of syphilis. The diagnosis of secondary syphilis primarily relies on the history of exposure, typical clinical manifestations, especially skin and mucosal lesions, combined with laboratory tests. The diagnosis of tertiary syphilis is mainly based on the history of exposure, typical clinical manifestations, and laboratory tests. Neurosyphilis can also be assessed through cerebrospinal fluid examination. Congenital syphilis primarily requires a maternal history of the disease, combined with typical clinical manifestations and laboratory tests for diagnosis.