AIDS and syphilis infections are both long-term processes. For example, a patient with primary syphilis mainly presents with a hard chancre. This can occur at locations such as the corona of the glans penis, the urinary meatus of the foreskin, the labia, the cervix, and also can be seen on the tongue, lips, breasts, and other places. At these locations, a hard chancre appears, which is painless and itchless, and presents as a round or oval, well-demarcated ulcer. The symptoms of AIDS are primarily seen in the early stages of the disease, and include fever, vomiting, fatigue, itchy skin, nodules, joint pain, and other symptoms of decreased immune function.