How to rescue from tetanus allergy

Written by Liu Huan Huan
General Surgery
Updated on March 15, 2025
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In clinical settings, when administering tetanus injections, it is very easy for allergic reactions to occur, even severe complications like anaphylactic shock. In such cases, the following emergency measures can be taken:

First, establish an intravenous access immediately, then start the patient on infusion therapy;

Second, if the patient experiences a drop in blood pressure, vasopressor agents can be used for pressor therapy;

Third, it's essential to provide the patient with cardiac monitoring, oxygenation, and other supportive treatments. In addition, it's crucial to use anti-allergy medications. There are many anti-allergic drugs available clinically, and the specific medication to be used should be decided based on the patient's specific condition.

(Please administer medications under the guidance of a professional physician, and do not self-medicate.)

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The likelihood of a wound being infected with tetanus

Tetanus is a specific infection often associated with trauma, with a high contamination rate of tetanus bacillus in traumatic wounds. On the battlefield, the contamination rate can reach 25% to 80%, although the incidence of tetanus in contaminated wounds is only about 10% to 20%. This suggests that other factors are necessary for the disease to occur, with the main factor being an anaerobic environment. If the wound is deep, with a small external opening, and contains necrotic tissue, blood clots, or is too tightly packed, this can lead to local ischemia. Additionally, if there is a co-infection with aerobic bacteria consuming residual oxygen in the wound, it creates an anaerobic environment conducive to the growth of the bacteria, thus increasing the likelihood of tetanus infection in the wound.

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chances of a person getting tetanus

Tetanus is a special type of infection that can enter the human body through skin, mucous membranes, or wounds and grows and reproduces in anaerobic conditions. The likelihood of a tetanus infection depends mainly on the depth and size of the wound, as well as what caused the wound. If the wound was caused by rusty nails or unclean sharp objects, and is both deep and large, the possibility of developing a tetanus infection is higher. Conversely, smaller or superficial wounds caused by relatively clean sharp objects are less likely to result in a tetanus infection.

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Can I get a tetanus shot in the emergency room?

The injection of tetanus shots is performed in the emergency department of regular hospitals. Tetanus shots are divided into tetanus toxoid, which requires a skin test, and tetanus immunoglobulin, which does not require a skin test. If the skin test for tetanus toxoid is positive, indicating an allergy, it cannot be injected, and must be replaced with the slightly more expensive tetanus immunoglobulin. It is generally recommended to administer the injection within 24 hours after injury to prevent infection by Clostridium tetani. Clostridium tetani is an anaerobic bacterium. It is necessary to administer tetanus treatment for injuries that are deep, in anaerobic conditions, contaminated, heavily contaminated with soil, rust, open fractures, etc., since these conditions can be conducive to tetanus infection.

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How long does tetanus antibody last?

The duration of tetanus antibodies varies under two scenarios. The first is passive immunity, which is achieved through injections such as tetanus antitoxin or tetanus immunoglobulin. The duration of immunity provided by these injections is relatively short. Typically, tetanus antitoxin lasts about four days, while tetanus immunoglobulin can last up to three weeks. After this period, the levels of antibodies gradually decrease, and the body may no longer be protected. Therefore, a single application of tetanus antitoxin or immunoglobulin does not provide long-lasting immunity. The second scenario involves antibodies produced by active immunity, generally through the injection of a vaccine made from attenuated tetanus bacilli. Antibodies usually start to develop about ten days after vaccination, with levels gradually increasing over two to three months and remaining high. This type of immunity lasts up to about ten years, but it is not lifelong. Regular boosters, guided by relevant tests, are required to maintain immunity.

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Where is the tetanus shot administered?

When there is a risk of tetanus infection due to contamination and suspected foreign objects in a wound, it is best to go to the hospital within 24 hours to get a tetanus vaccine. Currently, there are mainly two injection sites for the tetanus vaccine: one is the deltoid area of the upper arm, and the other is the upper outer side of the gluteus maximus in the buttocks. Most hospitals now advocate administering the tetanus injection in the gluteus maximus. After the injection, observe for half an hour before leaving.