How long does tetanus antibody last?

Written by Zhang Peng
General Surgery
Updated on March 08, 2025
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The duration of tetanus antibodies varies under two scenarios. The first is passive immunity, which is achieved through injections such as tetanus antitoxin or tetanus immunoglobulin. The duration of immunity provided by these injections is relatively short. Typically, tetanus antitoxin lasts about four days, while tetanus immunoglobulin can last up to three weeks. After this period, the levels of antibodies gradually decrease, and the body may no longer be protected. Therefore, a single application of tetanus antitoxin or immunoglobulin does not provide long-lasting immunity. The second scenario involves antibodies produced by active immunity, generally through the injection of a vaccine made from attenuated tetanus bacilli. Antibodies usually start to develop about ten days after vaccination, with levels gradually increasing over two to three months and remaining high. This type of immunity lasts up to about ten years, but it is not lifelong. Regular boosters, guided by relevant tests, are required to maintain immunity.

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Written by Zhang Peng
General Surgery
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How many years does the tetanus vaccine last?

Tetanus vaccines generally involve an active immunization process against tetanus with a complete immunization schedule, providing effective protection for up to ten years for those who have completed the full course of prevention. Typically, newborns must receive three doses of the DTP (diphtheria, tetanus, pertussis) vaccine, with the first dose administered at three months of age, followed by a dose each subsequent month, and booster shots at eighteen months or six years of age. If vaccinated, no further tetanus antitoxin or tetanus immunoglobulin injections are required for injuries incurred within ten years of vaccination. If no active immunization has been done and the wound is heavily contaminated, it is crucial to promptly administer tetanus antitoxin or tetanus immunoglobulin. A skin test must be performed before using tetanus antitoxin; if the test is strongly positive, immunoglobulin should be administered for preventive treatment.

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Written by Tang Da Wei
General Surgery
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Will a tetanus wound heal?

Tetanus wounds do not heal, and they contain a large amount of tetanus bacilli, which reproduce massively, leading to symptoms such as redness, pain, and even pus discharge in the affected area. Generally, these wounds cannot heal by themselves; even if the skin heals, the underlying and muscle tissues infected by tetanus can cause the skin to rupture and possibly accumulate pus. If a superficial wound is suspected to be infected with tetanus, it is necessary to promptly enlarge the wound, i.e., expand the surface wound, and rinse repeatedly with hydrogen peroxide and clean water to further kill the tetanus bacilli inside. At the same time, it is necessary to administer tetanus antitoxin, regularly observe the patient's clinical manifestations, and if necessary, administer tetanus antitoxin again after a period.

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Written by Ai Bing Quan
General Surgery
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What will happen with tetanus?

In clinical settings, tetanus is a type of surgical-specific infectious disease caused by the infiltration of Clostridium tetani through human skin, mucous membranes, or wounds. Tetanus toxin is a true anaerobic bacterium that thrives in oxygen-deprived environments and is highly resistant to environmental conditions. Clostridium tetani mainly produces tetanus toxin and tetanolysin, which can cause whole-body muscle spasms, including facial muscle spasms and difficulty opening the mouth. It can also lead to persistent spasms of the respiratory muscles and diaphragm, causing respiratory arrest and, in severe cases, can result in patient death.

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Written by Ai Bing Quan
General Surgery
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How to determine if a wound has tetanus

Tetanus wounds are mainly characterized by deep wound redness, accompanied by a certain degree of pain, and sometimes there is pus discharge. The incubation period is usually around seven days. After infection with Clostridium tetani, symptoms such as lockjaw and excessive arching of the back occur, which are caused by excessive muscle spasms. During the acute phase of clinical treatment, it is crucial to actively use antitoxins and antibiotics to treat the infection. Otherwise, muscle spasms may lead to paralysis of the respiratory muscles, ultimately resulting in death by suffocation. Prevention of tetanus is more important than treatment, and care should be taken to avoid injuries from rusty nails.

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Written by Liu Huan Huan
General Surgery
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Is tetanus an anaerobic bacterium?

Tetanus is a specific infection often associated with trauma. In addition to various traumas, it can also occur in parturient women and newborns under unsanitary conditions. The pathogen is Clostridium tetani, an obligate anaerobe that stains positive under Gram staining conditions. Normally present in the intestines of humans and animals, it is distributed in nature and common in soil. This type of bacteria has strong resistance to environmental conditions and can withstand boiling.