What are the initial symptoms of tetanus?

Written by Li Jin Quan
General Surgery
Updated on April 24, 2025
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Usually, the tetanus we talk about is a specific infection caused by the toxins produced by Clostridium tetani entering the body through the damaged skin and mucous membranes. Tetanus has some early symptoms and some characteristic symptoms during an attack. Early symptoms mainly include dizziness, headache, fatigue, decreased appetite, difficulty in chewing, some soreness in the jaw muscles, cyanosis of some muscles, or some reflexive muscle pain. If the condition worsens, it can enter a convulsive phase, characterized by lockjaw, difficulty in opening the mouth, a sardonic smile, and stiffness of the neck.

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Written by Gao Sen
General Surgery
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Tetanus 0.1ml how many units

In general, the dose of tetanus toxoid is 1500 international units per dose, approximately 1 ml per dose, and generally about 150 international units per 0.1 ml, which can be referred to the instructions. The use of tetanus toxoid should be avoided blindly and should be administered under the guidance of a physician. Additionally, wound cleaning and disinfection should be performed before administering tetanus toxoid. Furthermore, anti-infection treatment should be considered based on the contamination of the wound.

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Written by Xu Jun Hui
General Surgery
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Does a tetanus shot hurt?

The tetanus shot causes slight pain. The injection site is in the muscle of the buttocks, where the pain is mild and tolerable. The purpose of the tetanus shot is to prevent infection by the tetanus bacillus, which tends to thrive in anaerobic conditions and in heavily contaminated wounds, such as those with soil and rust. Therefore, patients with deep wounds contaminated with soil or rust must receive anti-tetanus treatment. Additionally, it is important to promptly treat and dress wounds to prevent infection by the tetanus bacillus and to prevent wound infection. The pain from the tetanus shot is minor.

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Written by Xu Jun Hui
General Surgery
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How to use a tetanus shot

If the wound is deeply infected in an anaerobic environment, or heavily contaminated, such as with polluted soil, rust, or in cases of open fractures, tetanus prophylaxis treatment is required. Tetanus treatment includes tetanus toxoid, which requires a skin test, and tetanus immunoglobulin, which does not require a skin test. The injection is generally administered in the buttock or the deltoid muscle of the upper arm. It is generally recommended to administer the injection within 24 hours of injury for optimal effectiveness, and it is advised not to drink alcohol before receiving the injection. Since most hospitals use tetanus toxoid because it is economical and affordable, a skin test is necessary, and patients with a positive skin test should not use it, instead, they should use tetanus immunoglobulin that does not require a skin test. Do not drink alcohol before the injection to avoid skin flushing, which can affect the results of the skin test.

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Written by Ai Bing Quan
General Surgery
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Is tetanus painful?

Tetanus is a specific infectious disease in surgery, caused by the exotoxin of Clostridium tetani. Tetanus infection can lead to rigid muscle spasms, which is a disease with a high mortality rate. Although its treatment is difficult, the prevention is effective, so tetanus infections can be avoided by vaccinating with the tetanus vaccine. The tetanus shot includes human tetanus immunoglobulin and tetanus antitoxin serum. The injection of human tetanus immunoglobulin is administered via muscle and is not very painful, generally tolerable. The injection of tetanus antitoxin serum, being a foreign protein to the body, requires an initial sensitivity test. The pain is evident, as the sensitivity test involves a skin prick.

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Written by Li Jin Quan
General Surgery
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Is tetanus serious?

In usual circumstances, when we diagnose tetanus, it is crucial to use a large amount of tetanus antitoxin and tetanus immunoglobulin early on to neutralize the toxins in the blood and alleviate the symptoms of tetanus. If tetanus severely manifests with symptoms such as muscle spasms, muscle rigidity, difficulty in opening the mouth, stiff neck, or complications like respiratory difficulty, respiratory failure, or even cessation of breathing and heartbeat, the condition can lead to severe complications and high mortality rates. Thus, tetanus becomes very severe in its late stages.