Tetanus is a specific infectious disease in surgery, caused by the exotoxin of Clostridium tetani. Tetanus infection can lead to rigid muscle spasms, which is a disease with a high mortality rate. Although its treatment is difficult, the prevention is effective, so tetanus infections can be avoided by vaccinating with the tetanus vaccine. The tetanus shot includes human tetanus immunoglobulin and tetanus antitoxin serum. The injection of human tetanus immunoglobulin is administered via muscle and is not very painful, generally tolerable. The injection of tetanus antitoxin serum, being a foreign protein to the body, requires an initial sensitivity test. The pain is evident, as the sensitivity test involves a skin prick.