If the wound is deeply infected in an anaerobic environment, or heavily contaminated, such as with polluted soil, rust, or in cases of open fractures, tetanus prophylaxis treatment is required. Tetanus treatment includes tetanus toxoid, which requires a skin test, and tetanus immunoglobulin, which does not require a skin test. The injection is generally administered in the buttock or the deltoid muscle of the upper arm. It is generally recommended to administer the injection within 24 hours of injury for optimal effectiveness, and it is advised not to drink alcohol before receiving the injection. Since most hospitals use tetanus toxoid because it is economical and affordable, a skin test is necessary, and patients with a positive skin test should not use it, instead, they should use tetanus immunoglobulin that does not require a skin test. Do not drink alcohol before the injection to avoid skin flushing, which can affect the results of the skin test.