How long does it take for tetanus to develop?

Written by Li Jin Quan
General Surgery
Updated on September 05, 2024
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Tetanus is a specific type of infection caused by the toxin produced by the growth and reproduction of Clostridium tetani, which enters the body through damaged skin and mucous membranes and thrives in an anaerobic environment. Clinically, it is mainly characterized by lockjaw, muscle rigidity, and muscle spasms. After being infected with tetanus, people generally show symptoms within seven to eight days; in quick cases, symptoms can appear within twenty-four hours, while in longer scenarios, the onset can take several months or even years.

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Written by Li Jin Quan
General Surgery
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Do you still need a skin test for tetanus allergy?

Under normal circumstances, if there is an allergy to tetanus, a skin test is not required. If tetanus vaccination is indeed necessary, human immunoglobulin can be injected, and this does not require a skin test. 250 units can be injected directly. Additionally, tetanus antitoxin desensitization injections can be used. The so-called desensitization injection involves diluting 1500 units of tetanus antitoxin into doses of 0.1 ml, 0.2 ml, 0.3 ml, and 0.4 ml, totaling 1 ml, and administering it in four doses, each 20 minutes apart. After the injections are completed, an observation period of 30 minutes is required to ensure there are no adverse reactions before the patient can leave.

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Written by Zhang Peng
General Surgery
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How is tetanus diagnosed?

For the diagnosis of tetanus, it mainly relies on relevant medical history and clinical manifestations. In terms of laboratory diagnosis, most cases involve culture of Clostridium tetani from wound tissue or polymerase chain reaction testing. Generally, a positive result can confirm a diagnosis of tetanus, but a negative result does not rule it out. Most laboratories are unable to perform these tests, and even if tetanus antibodies reach a protective level, it does not exclude a diagnosis of tetanus. If the patient has a clear history of injury or animal bites, and presents with symptoms such as lockjaw, a sardonic smile, muscle rigidity, difficulty swallowing, or persistent spasms, tetanus should be considered promptly and relevant treatment initiated.

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Written by Liu Huan Huan
General Surgery
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How long does a tetanus skin test take?

Tetanus is widely used clinically and is formally known as tetanus antitoxin. Therefore, if a patient is injured and the wound is deep, such as reaching the subcutaneous fat layer or even the muscle layer in severe cases, it is necessary to prevent tetanus infection by injecting tetanus antitoxin. Before injecting the tetanus antitoxin, it is mandatory to perform a skin test to prevent the patient from experiencing allergies, even severe clinical symptoms such as anaphylactic shock. During the skin test, generally, 0.1ml of tetanus antitoxin is diluted in 0.9ml of saline, and a skin test is performed on the forearm, observing for at least half an hour.

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Written by Li Jin Quan
General Surgery
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What are the initial symptoms of tetanus?

Usually, the tetanus we talk about is a specific infection caused by the toxins produced by Clostridium tetani entering the body through the damaged skin and mucous membranes. Tetanus has some early symptoms and some characteristic symptoms during an attack. Early symptoms mainly include dizziness, headache, fatigue, decreased appetite, difficulty in chewing, some soreness in the jaw muscles, cyanosis of some muscles, or some reflexive muscle pain. If the condition worsens, it can enter a convulsive phase, characterized by lockjaw, difficulty in opening the mouth, a sardonic smile, and stiffness of the neck.

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Written by Li Xiao Lin
Emergency Department
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What are the situations for tetanus shots?

Objects carrying tetanus bacillus, or tissues damaged by animals, require tetanus vaccination to prevent tetanus, such as rusty nails, animal claws, animal bites, venomous snake bites, and wounds contaminated by dirt can easily lead to infection by tetanus bacillus. Tetanus is a possible condition, so after an injury, it is necessary to immediately rinse the wound with soap and water or running water to wash away the toxins, which helps reduce the chance of infection. Then thoroughly disinfect the wound with iodophor, which can also reduce infection, and go to the hospital to receive tetanus antitoxin or tetanus immunoglobulin within 24 hours to prevent the onset of tetanus. The incubation period for tetanus is generally three to seven days, but it can be longer, so it is advised to go to the hospital for an injection as soon as possible after injury, to prevent the onset of the disease and avoid serious events.