What cold medicine should I take if I catch a cold from getting caught in the rain? It is mainly about choosing symptomatic treatment medicines. Getting caught in the rain leads to a decrease in immunity due to getting chilled, which can cause a viral infection and symptoms of a cold. If there is a fever, you can choose antipyretic analgesics such as ibuprofen or acetaminophen. If you have a sore throat, cough, or runny nose, you can choose vitamin-based medicines to promote the repair of tissue mucosa, in combination with medicines that dilute phlegm and control gland secretion for symptomatic treatment. Generally, antihistamines such as chlorpheniramine maleate can be chosen.