What is breast cancer OFS?

Written by Zhang Chao Jie
Breast Surgery
Updated on May 18, 2025
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Breast cancer OFS is a method in the field of breast cancer treatment, where OFS stands for ovarian function suppression. Thus, OFS refers to the suppression of ovarian function, preventing the ovaries from releasing sex hormones, thereby achieving the purpose of treating breast cancer. There are three methods of OFS. The first method is direct surgical removal, medically also called castration. Here, "castration" implies the removal of ovarian influence, and this surgical method is actually one of the most effective methods of OFS. The second method is chemical castration. The most commonly used drug for this is called Gosserelin, which is used for drug-induced ovarian function suppression. The third method of ovarian function suppression is radiotherapy. However, because it is difficult to achieve the desired results and it can cause serious complications, this method is basically no longer used. OFS is necessary for breast cancer patients who are positive for estrogen receptor ER and progesterone receptor PR, and it is used only under these conditions.

Other Voices

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Written by Gong Chun
Oncology
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Late-stage symptoms of breast cancer

The first symptom of advanced breast cancer is a lump in the breast, which may be larger than before, or there may be multiple lumps that are fixed to the surrounding tissues and have limited mobility. The second symptom is nipple discharge, which could be watery, serous, or milky. The third possible sign is changes in the skin, such as dimpling or an orange-peel texture. The fourth point includes the retraction of the nipple, abnormalities in the areola, and thickening and reddening of the nipple skin. The fifth point can involve pain in the breast. In advanced stages, the cancer may directly invade the nerves. Sixthly, advanced breast cancer may lead to metastases; for example, brain metastases might cause symptoms like nausea, vomiting, headaches, and dizziness. If there are bone metastases, especially multiple bone metastases, symptoms could include pain in the lower back and pain along the sciatic nerve, among others.

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Written by Zhang Chao Jie
Breast Surgery
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Breast Cancer Metastasizes to Which Locations

Breast cancer metastasis generally follows the following sites due to its anatomical structure and specific characteristics. The most common sites are the axilla, the contralateral breast, the contralateral axilla, and the areas above and below the clavicle, which is also known as the pipa bone, referring to the areas above and below the pipa bone. As for distant organs, based on the frequency or likelihood of occurrence, the most common are the lungs, bones, liver, and the brain, specifically within the head. These are referred to as the lungs, bones, liver, and head, which are the places most prone to distant organ metastasis.

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Written by Fan Hong Qiao
Breast Health Department
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What is invasive breast cancer?

Invasive breast cancer is the most common tumor in women, accounting for 22% of all malignant tumors in females. Invasive breast cancer refers to a malignant tumor where cancer cells have broken through the basement membrane of the breast ducts or lobular alveoli and invaded the interstitium. The vast majority of invasive breast cancers are adenocarcinomas, originating from the epithelial cells of the breast parenchyma, especially from the terminal duct lobular units. Its characteristics include the tumor's infiltration into adjacent tissues and a marked tendency for distant metastasis.

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Written by Lin Yang
Breast Surgery
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early symptoms of breast cancer

60% of early-stage breast cancer presents as a lump, most commonly in the upper outer quadrant. The primary symptoms include a painless, solitary, small lump that is hard, uneven in surface, irregular in shape, and not clearly demarcated from surrounding tissues. The lump is hard to move within the breast, indicating adhesion to the surrounding tissue. The skin over the lump may show signs of redness, swelling, indentation, orange peel-like texture, dimpling, and ulceration. Sometimes, there may also be nipple discharge, typically bloody, and early-stage enlargement of the axillary lymph nodes can occur.

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Written by Gong Chun
Oncology
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Breast cancer chemotherapy regimen

Breast cancer chemotherapy regimen. Thus, chemotherapy occupies a very important position in the treatment of breast cancer. The commonly used chemotherapy drugs in breast cancer treatment include alkylating agents, such as cyclophosphamide; antimetabolites like fluorouracil, methotrexate, gemcitabine, and capecitabine; anthracyclines, such as doxorubicin and others. In recent years, taxanes, particularly docetaxel, have been used more frequently. Other drugs include mitomycin and cisplatin, among others. However, the specific chemotherapy regimen for breast cancer should be assessed by a professional oncologist. The regimen should consider the pathological stage, pathological type, whether surgery was performed, whether the surgery completely removed the tumor, lymph node metastasis, and other factors to devise a suitable chemotherapy plan. Therefore, it is possible that each individual might have a regimen that is specifically suited to their situation, and not all regimens are suitable for everyone.