The first symptom of advanced breast cancer is a lump in the breast, which may be larger than before, or there may be multiple lumps that are fixed to the surrounding tissues and have limited mobility. The second symptom is nipple discharge, which could be watery, serous, or milky. The third possible sign is changes in the skin, such as dimpling or an orange-peel texture. The fourth point includes the retraction of the nipple, abnormalities in the areola, and thickening and reddening of the nipple skin. The fifth point can involve pain in the breast. In advanced stages, the cancer may directly invade the nerves. Sixthly, advanced breast cancer may lead to metastases; for example, brain metastases might cause symptoms like nausea, vomiting, headaches, and dizziness. If there are bone metastases, especially multiple bone metastases, symptoms could include pain in the lower back and pain along the sciatic nerve, among others.