The main symptoms of cholecystitis include upper abdominal pain. Mild cases generally are limited to the upper abdomen, while severe cases may affect the entire body, and 70% of patients with cholecystitis do not show any symptoms.

The early symptoms of cholecystitis can suddenly manifest as severe colicky pain in the upper right abdomen, which can also radiate to the right shoulder and back. These symptoms are generally triggered by consuming a large amount of fatty foods and are more likely to occur at night. If the condition progresses, the pain becomes persistent and progressively worsens, and may also be accompanied by mild to moderate fever. Some patients may experience chills and high fever, indicating that the condition is very severe.