How long does it take for cervical cancer to develop?

Written by Zhang Xiu Rong
Obstetrics and Gynecology
Updated on March 27, 2025
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Cervical cancer generally forms beginning with an infection of human papillomavirus (HPV), and it usually takes five to ten years to develop into cervical cancer. The vast majority of cervical cancer cases are caused by contact with HPV. If this virus continues to replicate in the body, it typically progresses to cervical cancer over a period of five to ten years. Therefore, cervical cancer screening is crucial for women. If regular check-ups are performed annually during this period, it is possible to halt the progression to cervical cancer and its precursors. Cervical cancer screening generally includes routine TCT (ThinPrep Cytologic Test) and HPV testing. These two tests can preliminarily screen for cervical cancer and precancerous conditions. If any abnormalities are detected, it is essential to undergo a colposcopic biopsy at a hospital, as biopsy is the gold standard for diagnosis.

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Precursors of cervical cancer

The occurrence and development of the cervix is a process from quantitative to qualitative change, evolving gradually to a sudden shift over a long period. The precursor might be the heterotypic zone of the cervix, which is a common site for abnormalities. During the formation of this heterotypic zone, cervical epithelial metaplasia is relatively active, and, compounded by infection with the human papillomavirus and further stimulated by external carcinogens, immature or proliferative squamous epithelial cells may exhibit gradual changes or atypical hyperplasia, potentially leading to sarcomatoid changes in the cervical epithelium. This might be a precursor sign.

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Written by Liu Jian Wei
Obstetrics and Gynecology
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How is cervical cancer screened?

Cervical cancer screening is a routine gynecological examination item for married women and women who are sexually active. Cervical cancer screening includes TCT (ThinPrep Cytologic Test) and HPV (Human Papillomavirus) tests. The TCT is a cytological examination of the cervix to determine if there are any cervical lesions based on cell morphology. HPV is the human papillomavirus, and its presence is a high-risk factor for cervical cancer. Therefore, cervical cancer screening consists of both TCT and HPV tests. If abnormalities are found in either test, a cervical biopsy may be necessary to confirm the presence of cervical lesions. It is best to conduct these tests between three to seven days after the end of menstruation.

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Cervical Cancer Staging Criteria

For the staging of cervical cancer, the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) are now adopted. Staging should be done before treatment, and since the FIGO staging of the cervix mainly relies on the examination of the pelvis, it is emphasized that the pelvic examination must be performed by two senior gynecologic oncologists. The staging primarily involves assessing the size of the cervical lesion, particularly the measurement of endophytic tumors, parametrial tissue infiltration, and the status of pelvic lymph nodes. However, these stages mainly rely on radiological examinations, primarily magnetic resonance imaging (MRI), to provide objective data for staging.

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Staging of cervical cancer

The clinical staging of cervical cancer mainly uses the FIGO system, which adopts the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO). Staging should be performed before treatment, and once done it does not change after treatment. Since FIGO staging of cervical cancer primarily relies on pelvic examination, it emphasizes the necessity of this examination being conducted by two experienced gynecologic oncologists. If needed, a pelvic examination under anesthesia is performed to ensure the accuracy of the evaluation. So, how is the staging performed? It involves measuring the size of the cervical lesion, particularly the measurement of endophytic tumors, the infiltration of cervical tissue, and the status of pelvic lymph nodes, providing accurate information with the aid of radiological data, especially magnetic resonance imaging (MRI).

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What is cervical cancer?

Cervical erosion is one of the most common malignant gynecological tumors, belonging to a type of cervical cancer. Cervical cancer itself is a significant branch within this category, and both the incidence and mortality rates of cervical cancer are relatively high in our country. However, recent advances in medical science have led to a noticeable decline. Cervical cancer is associated with HPV (Human Papillomavirus) infection, as well as with early childbirth, multiple pregnancies, and smoking. The definitive diagnosis of cervical cancer relies on the examination of cervical and endocervical canal live tissues, colposcopic biopsy, or cervical scrape cytology. Typically, after CT, MRI, or other imaging studies, a mass may be detected. Possible symptoms of cervical cancer include vaginal bleeding and vaginal discharge.