Patients with late-stage liver cancer may experience widespread pain, and the following treatments can be adopted: For pain caused by bone metastasis, in addition to providing opioids for symptomatic pain relief, local radiotherapy can also be administered to alleviate pain. If necessary, deep hyperthermia treatment can be given to the local metastatic lesions to relieve the pain. For widespread pain, treatment primarily involves the use of medications. The choice of medications can include opioids, supplemented by first-step antipyretic analgesics and medications that promote sleep, as pain tends to decrease when the patient is at rest. Additionally, for late-stage liver cancer patients experiencing widespread pain, an implanted pain pump can be used to control pain by periodically administering pain medication.