Will early-stage liver cancer cause a low-grade fever?

Written by Cui Fang Bo
Oncology
Updated on January 31, 2025
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Patients with early-stage liver cancer may experience low-grade fevers, primarily due to the following two reasons: First, tumor fever. In the early stages of liver cancer, some tumor cells can release tumor mediators into the bloodstream, affecting the function of the temperature regulation center and causing the patient to develop a fever. This type of tumor fever is usually not very high, remaining below 38.5°C, without concurrent symptoms or signs of infection. A complete blood count typically indicates that the total number of white blood cells and the proportion of neutrophils are not elevated. The second scenario involves patients in the early stages of liver cancer experiencing fever due to concurrent infections. These patients often present with symptoms and signs related to infection, such as coughing up phlegm, abdominal pain and diarrhea, and urinary frequency, urgency, or pain. The proportion of white blood cells and neutrophils is significantly increased in these cases.

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Does primary liver cancer have a genetic basis?

Primary liver cancer is generally not certain to be hereditary, but it may be somewhat related to genetics. For example, there are often phenomena of family and regional clustering of liver cancer. Current research believes that primary liver cancer, commonly referred to as liver cancer, is the result of a combination of factors, closely associated with hepatitis virus infection, aflatoxin infection, and contaminated drinking water. Common scenarios include hepatitis B virus infection leading to hepatitis B followed by cirrhosis, which can further develop into primary liver cancer. Also, long-term alcohol abuse leading to alcoholic cirrhosis can also result in liver cancer.

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The difference between primary liver cancer and secondary liver cancer

Primary liver cancer, also commonly referred to as liver cancer, originates in the liver itself and is not transferred from other parts of the body. Secondary liver cancer occurs when the primary tumor originates in another location and then metastasizes to the liver, causing hepatic space-occupying lesions; this is referred to as secondary liver cancer. The main difference between the two types is their origin. Additionally, primary liver cancer is often solitary but may develop intrahepatic or distant metastases as the disease progresses. In cases of secondary liver cancer, multiple intrahepatic metastatic lesions may be discovered at the onset. Moreover, primary liver cancer may often display an elevated alpha-fetoprotein tumor marker, whereas this marker might be normal in secondary liver cancer.

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What are the early symptoms of liver cancer?

The early symptoms of liver cancer lack specificity, so in clinical practice, early-stage liver cancer is generally detected only during routine screenings or physical examinations. By the time patients present with noticeable symptoms and seek medical attention, the cancer is often in the intermediate or advanced stages, making surgical removal unlikely for most patients. The early symptoms might include non-specific signs such as fatigue. It is usually only in the intermediate or advanced stages that patients experience obvious symptoms like pain in the liver area, palpable abdominal masses, abdominal distension, weight loss, and jaundice. By the time these symptoms appear, it is typically quite late, corresponding to the intermediate or advanced stages of the disease. Early stages typically do not show specific symptoms, though some patients might experience mild abdominal pain, bloating, or fatigue, which are not very specific signs.

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Can primary liver cancer be treated?

Primary liver cancer is also treatable. Generally, if the primary liver cancer is small and has not widely metastasized, surgical resection can be considered, mainly involving hepatectomy and lymph node dissection. Postoperative comprehensive treatment including chemotherapy and radiotherapy is also applied. For primary liver cancer, interventional chemotherapy, as well as methods like cryotherapy, microwave, and ablation can be considered to control the progression of the disease. Additionally, oral targeted therapy such as sorafenib can be used. If primary liver cancer is widely metastasized at the time of detection, there generally aren’t very effective treatment options, and the average survival period might be around six months, with poor treatment outcomes.

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Is increased lung markings related to liver cancer?

Increased pulmonary markings are clinically associated with many inducing factors, but they are not directly related to liver cancer. It's important to understand that liver cancer involves the presence of cancer cells in the liver, while increased pulmonary markings are radiographic signs observed during lung imaging examinations. Clinically, there are many factors that can lead to increased pulmonary markings, but liver cancer does not cause this condition. Typically, increased pulmonary markings may be due to excessive obesity, long-term smoking, or the presence of inflammatory lesions in the lungs, all of which can cause varying degrees of increased pulmonary markings.