How is liver cancer diagnosed?

Written by Liu Liang
Oncology
Updated on September 11, 2024
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In clinical practice, if a patient has a history of chronic hepatitis B and imaging tests, such as an enhanced CT or MRI of the liver, suggest a radiological appearance of liver cancer, combined with an AFP level greater than 400 persisting for four weeks, these conditions can support a clinical diagnosis of liver cancer. However, for a confirmed diagnosis, a liver biopsy guided by ultrasound or CT must be performed. The definitive diagnosis of liver cancer relies on identifying cancer cells through pathological examination.

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Written by Yan Chun
Oncology
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Will people with early-stage liver cancer experience weight loss?

Patients with early-stage liver cancer generally do not experience weight loss; weight loss is more commonly a clinical manifestation in patients with late-stage liver cancer. The reason for weight loss in liver cancer patients is due to the damage caused by cancerous tissue to liver function, leading to reduced synthesis of albumin. Furthermore, patients with liver cancer often experience a significant decrease in food intake, resulting in insufficient intake of nutrients such as albumin. Additionally, the progression of liver cancer tumors requires the consumption of a large amount of the body's albumin. Therefore, due to these factors, many patients with late-stage liver cancer exhibit clinical manifestations of weight loss. Moreover, besides not experiencing weight loss, patients with early-stage liver cancer also do not typically present with typical clinical symptoms. Many patients are asymptomatic, and as the lesion progresses, the cancer spreads, possibly leading to clinical manifestations associated with tumor spread. For example, pain in the liver area, a significant decrease in food intake, fatigue, fever, pain, and some patients may also exhibit symptoms of metastasis such as headaches, vomiting, abdominal pain, and abdominal distension.

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Written by Cui Fang Bo
Oncology
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How to reduce fever in late-stage liver cancer

For late-stage liver cancer patients experiencing fever, antipyretic treatment should be based on different circumstances. If the fever is due to an infection, it often exceeds 39℃ and is accompanied by symptoms and signs related to the infection, such as cough and yellow sputum, abdominal pain, diarrhea, frequent urination, urgency, and painful urination. In such cases, antibiotics should be used for anti-infective treatment, along with antipyretic analgesics for fever reduction. If the fever is due to tumor fever or interventions like liver procedures, there are no infection-related factors, usually the temperature does not exceed 38.5℃, and there are no symptoms or signs related to infection. The treatment primarily involves the use of antipyretic analgesics for fever reduction.

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Written by Sun Wei
Surgical Oncology
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The difference between primary liver cancer and secondary liver cancer.

Primary liver cancer generally refers to tumors whose cancer cells originate from the liver itself or from the intrahepatic bile ducts. Secondary liver cancer usually refers to cancer that has metastasized to the liver from other parts of the body, which is the main difference between the two. Additionally, primary liver cancer might progress rapidly, potentially resulting in a short survival time, especially in cases of large, inoperable tumors, where most survival times range from half a year to about a year. In contrast, secondary liver cancer might have a longer survival time, and initial symptoms are generally milder. Also, tumor markers like alpha-fetoprotein (AFP) tend to be higher in primary liver cancer, whereas in secondary liver cancer, this marker may be normal.

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Written by Yan Chun
Oncology
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Can early-stage liver cancer be cured by resection?

Liver cancer is one of the common malignant tumors of the digestive system. For patients with early-stage liver cancer, clinical cure is possible after curative surgery. This clinical cure refers to instances where liver cancer patients, after undergoing curative surgery, do not show signs of recurrence or metastasis over a period exceeding five years. This means there is no invasion of surrounding tissues and no metastasis to distant organs – effectively, the patients have achieved clinical cure. Patients' survival time exceeds five years, or even longer. Therefore, for patients with early-stage liver cancer, because their lesions are relatively limited, achieving clinical cure is possible following curative surgery. However, as the disease progresses to the mid and late stages, even with aggressive surgery and postoperative adjuvant radiotherapy or chemotherapy, most patients cannot achieve clinical cure.

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Written by Sun Wei
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Is primary liver cancer contagious?

Primary liver cancer refers to malignant tumors that occur in the liver and are not metastasized from other parts of the body. Such liver cancer itself is not contagious. However, if liver cancer patients have other infectious diseases, transmission may be possible. Most primary liver cancers are related to liver cirrhosis following hepatitis, with hepatitis B being the most common. If accompanied by hepatitis B, it can be contagious, but it usually doesn't spread through regular daily contact. The main transmission routes for hepatitis B are through blood, mother-to-child transmission, and sexual transmission. This means that as long as the patient's blood does not injure someone else, contagion is generally unlikely, so there is no need for excessive worry.