Early symptoms of primary liver cancer

Written by Sun Wei
Surgical Oncology
Updated on August 31, 2024
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Primary liver cancer often shows no obvious symptoms in its early stages. It may present symptoms similar to indigestion, hepatitis, etc. For example, there might be slight discomfort or pain in the upper right abdomen, aversion to oil, or loss of appetite. Generally, regular health check-ups are needed, including imaging studies of the liver such as ultrasound, CT, or MRI. Liver function tests and tumor markers such as alpha-fetoprotein (AFP) should also be performed. In most cases of primary liver cancer, AFP levels will be elevated. Combined with imaging studies, a preliminary diagnosis can be made. A definitive diagnosis requires liver biopsy or confirmation through pathology after surgery.

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Surgical Oncology
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Does primary liver cancer have a genetic basis?

Primary liver cancer is generally not certain to be hereditary, but it may be somewhat related to genetics. For example, there are often phenomena of family and regional clustering of liver cancer. Current research believes that primary liver cancer, commonly referred to as liver cancer, is the result of a combination of factors, closely associated with hepatitis virus infection, aflatoxin infection, and contaminated drinking water. Common scenarios include hepatitis B virus infection leading to hepatitis B followed by cirrhosis, which can further develop into primary liver cancer. Also, long-term alcohol abuse leading to alcoholic cirrhosis can also result in liver cancer.

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Written by Wang Chun Mei
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Is increased lung markings related to liver cancer?

Increased pulmonary markings are clinically associated with many inducing factors, but they are not directly related to liver cancer. It's important to understand that liver cancer involves the presence of cancer cells in the liver, while increased pulmonary markings are radiographic signs observed during lung imaging examinations. Clinically, there are many factors that can lead to increased pulmonary markings, but liver cancer does not cause this condition. Typically, increased pulmonary markings may be due to excessive obesity, long-term smoking, or the presence of inflammatory lesions in the lungs, all of which can cause varying degrees of increased pulmonary markings.

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Written by Yan Chun
Oncology
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Should the gallbladder be removed in the early stage of liver cancer?

Whether early-stage liver cancer patients need to have their gallbladder removed depends on the location of the tumor. For liver cancers located close to the gallbladder, gallbladder removal is generally necessary. For liver cancer lesions that are farther from the gallbladder, it is usually sufficient to only remove the liver tumor, or to perform a resection of the local liver segment or sub-segment. Additionally, for early-stage liver cancer patients to undergo surgery, certain conditions must be met: the tumor must be five centimeters or smaller, there should be no cancerous thrombus in the main trunk of the portal vein, the liver cancer tumor should not involve the semi-dry or full-dry circumstances, and the liver function should be compensatory. Under these conditions, an effort should be made to perform liver tumor resection. Generally, cancers located in the left lobe of the liver require local resection, either of a liver segment or sub-segment, and sometimes resection of the liver lobe may be performed. Tumors located in the right lobe of the liver or the hepatic portal area require local tumor resection.

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Written by Sun Wei
Surgical Oncology
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The difference between primary liver cancer and metastatic liver cancer

Primary liver cancer refers to malignant tumors that originate in the liver, while metastatic liver cancer refers to cancers that start in other parts of the body and then spread to the liver through lymphatic and blood circulation, among other routes. Another difference is that primary liver cancer is more likely to be a single lesion, while metastatic liver cancer generally involves multiple lesions. Regarding the differences between primary and metastatic liver cancer, their treatment methods also differ. For primary liver cancer, interventional chemotherapy or surgery, such as hepatic lobectomy, can be performed if the tumor is small. In contrast, metastatic liver cancer usually involves multiple lesions, making surgery alone challenging. Additionally, the primary tumor also requires treatment.

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Written by Sun Wei
Surgical Oncology
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Which is more treatable, primary liver cancer or metastatic liver cancer?

Primary liver cancer refers to malignant tumors that originate in the liver, while metastatic liver cancer refers to malignant tumors from other parts of the body that have spread to the liver. As to which is easier to treat, it is generally difficult to determine and depends on the control of the primary lesion in cases of metastatic liver cancer; both might be challenging to treat. However, if the lesion in primary liver cancer is relatively small, there may still be an opportunity for surgical treatment. In general, metastatic liver cancer is not amenable to curative surgery because the primary lesion also requires treatment. But in terms of the rate of progression or severity, metastatic liver cancer might progress more slowly, while primary liver cancer generally progresses quite rapidly, making it also very difficult to treat.