Can alpha-fetoprotein diagnose liver cancer?

Written by Zhang Lu
Obstetrics
Updated on March 13, 2025
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Alpha-fetoprotein, also known as AFP, reflects the function of the liver and whether there are any diseases present. The accuracy and specificity of alpha-fetoprotein in diagnosing liver cancer are relatively high. In non-pregnant individuals, whether male or female, an elevated alpha-fetoprotein level should raise suspicions of liver disease, and it is advisable to promptly undergo ultrasound or CT scans to determine the presence of liver cancer or other liver diseases. However, during pregnancy, as the fetus grows and develops, a certain amount of alpha-fetoprotein is released. Therefore, when testing the blood of pregnant women, an increase in alpha-fetoprotein is observed. This condition is a physiological change and does not indicate the occurrence of liver diseases such as liver cancer in women. Thus, alpha-fetoprotein can serve as an auxiliary method for diagnosing liver cancer, but only in non-pregnant individuals.

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Liver cancer patients are generally advised not to drink milk, particularly in cases of advanced liver cancer where there is a potential for hepatic encephalopathy. This is because, for patients in the late stages of liver cancer, liver function is compromised, and some may already exhibit symptoms indicative of pre-hepatic encephalopathy. Consuming a diet rich in protein can easily trigger hepatic encephalopathy, and since milk is high in protein, its consumption is usually limited or avoided in such patients. However, for the majority of liver cancer patients, drinking milk is permissible as it not only contains abundant protein but also rich calcium, which is beneficial for the recovery of liver cancer patients. Most liver cancer patients have hypoalbuminemia (low levels of protein in the blood) and some also have hypocalcemia (low levels of calcium in the blood), thus the intake of calcium and protein-rich foods can be very beneficial for their recovery.

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Can hepatitis B turn into liver cancer?

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Is the alpha-fetoprotein high in the early stage of liver cancer?

Patients with liver cancer may not necessarily have elevated carcinoembryonic antigen (CEA) levels in the early stages. CEA, a commonly used tumor marker, tends to increase in various types of malignancies. However, an elevation in CEA is not necessarily linked to the occurrence of malignant tumors. Many patients with early-stage tumors, including liver cancer, may not have elevated CEA levels at diagnosis. Conversely, elevated CEA levels in some patients may be due to benign conditions and not necessarily indicate malignancy. Therefore, it is unreasonable to determine the presence of liver cancer solely based on the elevation of CEA.

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Is primary liver cancer prone to metastasis?

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Does primary liver cancer have a genetic basis?

Primary liver cancer is generally not certain to be hereditary, but it may be somewhat related to genetics. For example, there are often phenomena of family and regional clustering of liver cancer. Current research believes that primary liver cancer, commonly referred to as liver cancer, is the result of a combination of factors, closely associated with hepatitis virus infection, aflatoxin infection, and contaminated drinking water. Common scenarios include hepatitis B virus infection leading to hepatitis B followed by cirrhosis, which can further develop into primary liver cancer. Also, long-term alcohol abuse leading to alcoholic cirrhosis can also result in liver cancer.