Will early-stage liver cancer cause weight loss?

Written by Yan Chun
Oncology
Updated on May 21, 2025
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For patients with early-stage liver cancer, symptoms of wasting do not occur at the onset. This is because wasting in liver cancer patients is due to insufficient albumin synthesis as the tumor causes a substantial consumption of protein, coupled with a decrease in appetite leading to inadequate intake of nutrients such as albumin, which ultimately results in wasting. This is a common clinical manifestation in patients with advanced liver cancer. However, for patients with early-stage liver cancer, the impairment of liver function is relatively minor; therefore, their synthesis of albumin is normal. Moreover, early-stage patients exhibit almost no clinical symptoms and their appetite remains normal, with no decrease in food intake. Thus, their intake of nutrients is also maintained at normal levels. Additionally, as the tumor is smaller in the early stages, the consumption of the body's nutrients is less. Considering these three factors, the overall protein consumption remains normal and not excessive, thus preventing the patients from experiencing wasting.

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