Will early-stage liver cancer cause weight loss?

Written by Yan Chun
Oncology
Updated on May 21, 2025
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For patients with early-stage liver cancer, symptoms of wasting do not occur at the onset. This is because wasting in liver cancer patients is due to insufficient albumin synthesis as the tumor causes a substantial consumption of protein, coupled with a decrease in appetite leading to inadequate intake of nutrients such as albumin, which ultimately results in wasting. This is a common clinical manifestation in patients with advanced liver cancer. However, for patients with early-stage liver cancer, the impairment of liver function is relatively minor; therefore, their synthesis of albumin is normal. Moreover, early-stage patients exhibit almost no clinical symptoms and their appetite remains normal, with no decrease in food intake. Thus, their intake of nutrients is also maintained at normal levels. Additionally, as the tumor is smaller in the early stages, the consumption of the body's nutrients is less. Considering these three factors, the overall protein consumption remains normal and not excessive, thus preventing the patients from experiencing wasting.

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Written by Yan Chun
Oncology
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Does early-stage liver cancer cause the complexion to become dark?

Patients with early-stage liver cancer do not experience darkening of the facial complexion. This is because early-stage liver cancer primarily refers to carcinoma in situ of the liver and some small liver cancers. Since the tumors are small and the affected area is limited, they generally cause few symptoms clinically. Some patients may experience mild fatigue and a decrease in appetite, but these do not lead to changes in the complexion. Only when the liver cancer progresses to the middle or late stages, causing damage to liver cell functions or when the pathology metastasizes, leading to damage to multiple organ functions, can there be some changes in facial complexion. For example, patients may exhibit pale complexions due to moderate to severe anemia. Some patients may have yellowing of the skin due to obstructive jaundice or hepatocellular jaundice. Additionally, some patients may show darkening of the facial complexion due to abnormal hormone secretion.

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Written by Du Ning
Hepatobiliary Surgery
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Can gallbladder stones turn into liver cancer?

Long-term pathological changes from hepatobiliary calculi can lead to liver cancer. Hepatobiliary calculi generally refer to intrahepatic bile duct stones. When these stones grow in a single duct and gradually increase in number and size, they can cause obstruction of the bile duct. Obstruction of the bile duct subsequently leads to cholangitis, which involves repeated inflammatory irritation. This, in turn, can cause malignant transformation of the bile duct cells. Following this transformation, a tumor forms, which can develop into cholangiocellular carcinoma, a type of liver cancer. Therefore, if intrahepatic bile duct stones cause long-term inflammatory stimulation, it can lead to cancerous changes and result in liver cancer. Thus, if intrahepatic bile duct stones have already caused noticeable clinical symptoms such as abdominal pain, fever, and liver function abnormalities, aggressive surgical treatment should be considered.

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Written by Liu Liang
Oncology
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What to do if vomiting occurs in liver cancer?

Liver cancer is divided into two main pathological types, the first being hepatocellular carcinoma, which is the most common, and the other being cholangiocellular carcinoma. Clinically, vomiting is also a common symptom of liver cancer. For symptomatic treatment, we can provide gastric protection and administer antiemetic drugs such as stomach comfort, but these are only symptomatic treatments and do not cure the root cause. The key is still to treat the liver cancer itself, as the symptoms will only alleviate once the cancer is under control. For advanced hepatocellular carcinoma, targeted therapies like sorafenib are available. If it is cholangiocellular carcinoma, and symptoms like vomiting and jaundice appear, which may be obstructive symptoms, then a surgical procedure in hepato-biliary surgery to drain the bile can be performed, which can also alleviate the symptoms of vomiting. (Medications should be used under the guidance of a doctor.)

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Written by Sun Wei
Surgical Oncology
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The difference between primary liver cancer and secondary liver cancer.

Primary liver cancer generally refers to tumors whose cancer cells originate from the liver itself or from the intrahepatic bile ducts. Secondary liver cancer usually refers to cancer that has metastasized to the liver from other parts of the body, which is the main difference between the two. Additionally, primary liver cancer might progress rapidly, potentially resulting in a short survival time, especially in cases of large, inoperable tumors, where most survival times range from half a year to about a year. In contrast, secondary liver cancer might have a longer survival time, and initial symptoms are generally milder. Also, tumor markers like alpha-fetoprotein (AFP) tend to be higher in primary liver cancer, whereas in secondary liver cancer, this marker may be normal.

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Common symptoms of primary liver cancer

The initial symptoms of primary liver cancer are mostly pain in the liver area, which commonly presents as abdominal pain. Some patients may also experience bloating, fatigue, and weight loss as systemic symptoms. In advanced-stage liver cancer patients, there can be an enlargement of the liver, meaning a palpable enlarged mass can be felt in the abdomen. Other symptoms include jaundice and ascites, which can cause abdominal bloating. Upon physical examination, an obvious increase in abdominal girth and abdominal distension can be noted. Moreover, patients with advanced liver cancer may also suffer from complications such as upper gastrointestinal bleeding, rupture and bleeding of the liver cancer nodules, liver failure, and even hepatic encephalopathy, among others.