Patients with severe hepatitis B, if not treated in time or improperly or for an inadequate duration, may progress to develop liver cirrhosis. A portion of those with cirrhosis might then develop liver cancer. Therefore, patients with severe hepatitis B could potentially develop liver cancer if left untreated or not properly treated. Therefore, once diagnosed with hepatitis B, particularly severe forms, prompt and standardized treatment should be sought to achieve an antiviral response against hepatitis B and prevent the occurrence of liver cirrhosis and liver cancer.