What are the symptoms of Helicobacter pylori?

Written by Si Li Li
Gastroenterology
Updated on June 27, 2025
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After Helicobacter pylori infection, many patients show no symptoms, while others may develop chronic gastritis, peptic ulcers, and even gastric cancer as a result of the infection, manifesting symptoms such as upper abdominal pain, burping, acid reflux, nausea, vomiting, heartburn, and indigestion. Therefore, if you are infected with Helicobacter pylori and experience the above symptoms, it is recommended to undergo a gastroscopy to confirm the diagnosis. After a clear diagnosis, treatment can be tailored to the specific disease. A 14-day eradication therapy for Helicobacter pylori is recommended, involving a proton pump inhibitor, two antibiotics, and a bismuth agent, for a total treatment duration of 14 days. Dietary suggestions include eating divided meals and using serving chopsticks, which can significantly reduce the infection rate of Helicobacter pylori.

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How to eradicate Helicobacter pylori

The spontaneous clearance rate of Helicobacter pylori infection is extremely low, meaning that it is almost impossible to cure itself. If not treated medically, it may lead to a lifelong infection. Currently, the consensus both domestically and internationally on handling Helicobacter pylori is that eradication requires combination therapy with multiple drugs, categorized into triple therapy and quadruple therapy, with a treatment duration of 2 weeks. Triple therapy consists of a proton pump inhibitor (PPI) plus two antibiotics. We currently use quadruple therapy, which includes two antibiotics, a gastric mucosal protectant, and a proton pump inhibitor. The choice of these drugs is complex. Common anti-inflammatory drugs include amoxicillin, clarithromycin, metronidazole, and levofloxacin; in cases of bacterial resistance, we recommend using furazolidone or tetracycline. Specific medications should be consulted in detail with a doctor. After the treatment course, we need to assess whether the eradication was successful, with a re-examination one month after stopping the drugs. After the eradication of Helicobacter pylori, the rate of reinfection in adults is very low, but the reinfection rate in children is somewhat higher than in adults. Not everyone infected with Helicobacter pylori needs eradication; it is necessary only for those with ulcers, erosion, atrophy, or related symptoms.

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Helicobacter pylori symptoms

Helicobacter pylori itself is just a bacterium, often parasitizing the stomach or oral cavity of the human body. It cannot be said that Helicobacter pylori has symptoms, but rather that symptoms may occur after being infected by Helicobacter pylori. Many normal people infected with Helicobacter pylori may not exhibit any discomfort. However, if Helicobacter pylori causes gastritis or peptic ulcers, etc., related symptoms may appear. For instance, abdominal pain, bloating, belching, acid reflux, and so on; in cases of peptic ulcers, corresponding symptoms, such as periodic, recurrent episodes of upper abdominal pain associated with eating and so forth, may also occur and will need to be determined based on the specific situation.

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Can treatment for Helicobacter pylori be stopped at any time?

During the treatment of Helicobacter pylori, it is not advisable to stop the medication arbitrarily, as doing so may lead to insufficient treatment duration and result in a failure to eradicate the bacteria. Therefore, it is recommended to use a bismuth-containing quadruple therapy for two weeks to eradicate Helicobacter pylori. The specific medications included in this two-week quadruple therapy are a proton pump inhibitor such as pantoprazole or lansoprazole, plus two antibiotics such as amoxicillin, clarithromycin, or metronidazole, combined with bismuth potassium citrate. The medication should be taken under medical supervision. Helicobacter pylori infection can be detected through a carbon-13 breath test or a carbon-14 breath test.

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Written by Si Li Li
Gastroenterology
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What are the early symptoms of Helicobacter pylori infection?

Helicobacter pylori can cause chronic gastritis, peptic ulcers, and even stomach cancer. Infection with Helicobacter pylori may result in symptoms such as upper abdominal distension and pain, belching, acid reflux, nausea, vomiting, poor appetite, bad breath, and indigestion. A carbon-14 breath test can confirm a Helicobacter pylori infection. Currently, the infection rate of Helicobacter pylori in our country has exceeded 50%. If an infection is present and symptoms or diseases of the digestive system occur, eradication treatment for Helicobacter pylori is necessary. The treatment regimen consists of a proton pump inhibitor, two types of antibiotics, and a bismuth agent, adjusted to a 14-day course.

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What are the symptoms of Helicobacter pylori infection?

Helicobacter pylori is a pathogen produced in the stomach or oral cavity. It cannot be said that Helicobacter pylori causes any specific symptoms, rather, it is the infection of Helicobacter pylori that leads to a series of diseases presenting symptoms. Some people infected with Helicobacter pylori may not show any symptoms at all. If related diseases occur, such as gastritis or ulcers, symptoms such as acid reflux, heartburn, nausea, and vomiting may appear. Additionally, some patients, like those with refractory iron deficiency anemia or idiopathic thrombocytopenic purpura, may also have conditions associated with Helicobacter pylori infection.