What are the early symptoms of Helicobacter pylori infection?

Written by Si Li Li
Gastroenterology
Updated on February 19, 2025
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Helicobacter pylori can cause chronic gastritis, peptic ulcers, and even stomach cancer. Infection with Helicobacter pylori may result in symptoms such as upper abdominal distension and pain, belching, acid reflux, nausea, vomiting, poor appetite, bad breath, and indigestion. A carbon-14 breath test can confirm a Helicobacter pylori infection. Currently, the infection rate of Helicobacter pylori in our country has exceeded 50%. If an infection is present and symptoms or diseases of the digestive system occur, eradication treatment for Helicobacter pylori is necessary. The treatment regimen consists of a proton pump inhibitor, two types of antibiotics, and a bismuth agent, adjusted to a 14-day course.

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Written by Wu Hai Wu
Gastroenterology
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Reactions during the treatment of Helicobacter pylori

During the treatment of Helicobacter pylori, there usually isn't significant discomfort, but a small number of patients may experience upper abdominal discomfort, nausea, vomiting, and other symptoms after taking antibiotics. Treatment of Helicobacter pylori requires a two-week quadruple therapy including a bismuth-containing agent. During the treatment of Helicobacter pylori infection, it is recommended to consume fresh vegetables and fruits rich in vitamins, avoid spicy and irritating foods, quit smoking and drinking, and avoid strong tea and coffee. Furthermore, it is advisable to avoid overeating and drinking excessively during the treatment period.

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Written by Wu Hai Wu
Gastroenterology
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How many times a year should Helicobacter pylori be tested?

If Helicobacter pylori tests positive, then it is necessary to undergo standardized eradication treatment. A re-examination is needed one month after cessation of the eradication treatment to confirm whether the eradication was successful or the treatment failed. If the patient tests negative for Helicobacter pylori, then there is no need for repeated testing. Therefore, the frequency of testing for Helicobacter pylori within a year needs to be analyzed based on specific circumstances, using different testing methods and frequencies according to different situations. Patients infected with Helicobacter pylori should eat light, easily digestible foods, avoid overeating, and avoid spicy and irritating foods.

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Written by Wu Hai Wu
Gastroenterology
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Can I take vitamins B1 and B12 during treatment for Helicobacter pylori?

During the treatment of Helicobacter pylori, it is possible to consume Vitamin B1 and Vitamin B12. The treatment of Helicobacter pylori infection can consider using a bismuth-containing quadruple therapy for two weeks to eradicate the infection. During the treatment of Helicobacter pylori infection, one can also eat fresh vegetables and fruits rich in vitamins, such as kiwis, bananas, apples, etc. It is important to eat regularly and in moderation, consume light, easily digestible foods, and avoid overeating. Spicy and stimulative foods should be avoided, including strong alcohol, strong tea, coffee, etc. At the same time, patients with Helicobacter pylori infection should also ensure adequate rest.

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Written by Huang Ya Juan
Gastroenterology
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How to eradicate Helicobacter pylori

The spontaneous clearance rate of Helicobacter pylori infection is extremely low, meaning that it is almost impossible to cure itself. If not treated medically, it may lead to a lifelong infection. Currently, the consensus both domestically and internationally on handling Helicobacter pylori is that eradication requires combination therapy with multiple drugs, categorized into triple therapy and quadruple therapy, with a treatment duration of 2 weeks. Triple therapy consists of a proton pump inhibitor (PPI) plus two antibiotics. We currently use quadruple therapy, which includes two antibiotics, a gastric mucosal protectant, and a proton pump inhibitor. The choice of these drugs is complex. Common anti-inflammatory drugs include amoxicillin, clarithromycin, metronidazole, and levofloxacin; in cases of bacterial resistance, we recommend using furazolidone or tetracycline. Specific medications should be consulted in detail with a doctor. After the treatment course, we need to assess whether the eradication was successful, with a re-examination one month after stopping the drugs. After the eradication of Helicobacter pylori, the rate of reinfection in adults is very low, but the reinfection rate in children is somewhat higher than in adults. Not everyone infected with Helicobacter pylori needs eradication; it is necessary only for those with ulcers, erosion, atrophy, or related symptoms.

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Written by Jiang Guo Ming
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Can a gastroscopy detect Helicobacter pylori?

First, it is important to clarify that a gastroscopy and a Helicobacter pylori test are two completely different methods. Generally speaking, a gastroscopy cannot detect whether there is a Helicobacter pylori infection. A gastroscopy specifically involves passing through the pharynx, esophagus, stomach, and finally reaching the descending part of the duodenum. It allows clear observation of whether there is inflammation, ulcers, or neoplastic diseases in the upper gastrointestinal tract, and it is the clearest and most direct method for examining the upper gastrointestinal tract. Helicobacter pylori testing, on the other hand, can generally be conducted in several ways. Firstly, blood can be drawn to test for Helicobacter pylori antibodies. Secondly, a breath test can be done, which is currently the most commonly used method, such as the carbon-13 or carbon-14 breath tests. Other methods include taking a biopsy during gastroscopy for a rapid urease test, and culturing bacteria from a biopsy. Therefore, gastroscopy cannot be used to test for Helicobacter pylori.