Mild ventricular septal defects generally do not cause hypoxia. If symptoms of hypoxia recur due to a ventricular septal defect, it is recommended to undergo minimally invasive interventional treatment or surgical treatment at a hospital to prevent further episodes.

The success rate of this surgery is very high, almost 100%, with relatively few complications. If hypoxia occurs in untreated ventricular septal defects, initial therapy should include oxygen administration, followed by diuretic, cardiotonic, and other treatments to reduce cardiac load at a hospital, and surgery should be considered as soon as suitable.