Generally, premature birth is not related to ventricular septal defect. Although a premature infant is born early, their heart structure, lungs, and other body structures are normal. Ventricular septal defect is often caused by a developmental disorder of the septum during the fetal period, manifesting as left-to-right or right-to-left shunting. Generally, patients with a simple ventricular septal defect can survive normally. They can be completely cured through interventional treatment or surgical surgery, so there is no need to worry excessively. There is no direct connection between ventricular septal defect and premature birth.