Sinusitis, commonly referred to as sinus inflammation, mainly involves the mucosal membrane of the sinus cavity or the sinus itself. In the clinical course of the disease, we have not observed sinusitis or secondary sinusitis directly transforming into a malignant tumor, nor have we seen or observed the carcinogenic process. Clinically or pathologically, there is no evidence of this. However, we have observed malignant tumors of the sinuses, such as maxillary sinus cancer or ethmoid sinus cancer. It is found that 80% to 85% of these patients have sinus inflammation. Therefore, we speculate that sinusitis may be evolving into sinus cancer, or inflammation may play a role in the process of sinus cancer. In summary, there is no direct evidence that secondary sinusitis leads to cancer, but in diagnosing sinus cancer, the presence of sinus inflammation has been observed.