Clinical manifestations of breast cancer

Written by Lin Yang
Breast Surgery
Updated on February 15, 2025
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The clinical manifestations of breast cancer mostly present as painless lumps in the breast. Many early-stage breast lumps are found during physical examinations or screenings. Lumps commonly develop in the upper outer quadrant and are typically solitary on one side, though occasionally there are multiple lumps, or they may appear bilaterally. The size of the clinically observed lumps varies, with diameters of up to 5 centimeters being common. Generally, the lumps are hard in consistency, have unclear boundaries, and are not easily movable within the breast. Sometimes, the nipple may be inverted and there may be bloody discharge. Enlarged lymph nodes may also be present under the armpit.

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Written by Lin Yang
Breast Surgery
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early symptoms of breast cancer

60% of early-stage breast cancer presents as a lump, most commonly in the upper outer quadrant. The primary symptoms include a painless, solitary, small lump that is hard, uneven in surface, irregular in shape, and not clearly demarcated from surrounding tissues. The lump is hard to move within the breast, indicating adhesion to the surrounding tissue. The skin over the lump may show signs of redness, swelling, indentation, orange peel-like texture, dimpling, and ulceration. Sometimes, there may also be nipple discharge, typically bloody, and early-stage enlargement of the axillary lymph nodes can occur.

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Written by Gong Chun
Oncology
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Early-stage breast cancer symptoms

Early-stage breast cancer may exhibit several symptoms. The first is the presence of breast lumps. The second symptom might be nipple discharge, which can be serous, watery, or milky in nature. The third symptom might involve changes in the skin over the breast tumor, including skin adhesion, such as dimpling, engorgement of superficial veins, skin reddening, localized increase in temperature, and an orange-peel texture. The fourth symptom includes abnormalities of the nipple and areola, potentially featuring nipple retraction, erosion of the nipple, thickening of the nipple epithelium, and reddening. The fifth symptom could be breast pain.

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Written by Cui Fang Bo
Oncology
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Early symptoms of breast cancer

The symptoms of early-stage breast cancer mainly include breast lumps, abnormal nipple discharge, and changes in breast skin. Breast cancer is a common type of malignant tumor among women in China, with adenocarcinoma being the most common pathological type, although other types can also be seen clinically. Patients exhibiting abnormal breast lumps, abnormal nipple discharge, and changes in breast skin should consider the possibility of breast cancer. Patients suspected of having breast cancer should undergo breast imaging tests, including mammography and breast MRI, among others. Patients in whom abnormal breast masses are found during imaging tests can obtain a definitive diagnosis by surgical removal or percutaneous biopsy. Patients diagnosed with breast cancer should undergo surgical treatment as soon as possible.

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Written by Fan Hong Qiao
Breast Health Department
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Differences between Breast Hyperplasia and Breast Cancer

Both breast hyperplasia and breast cancer can present as breast lumps. The lumps in breast hyperplasia are generally softer or of medium hardness, often occurring bilaterally with multiple lumps of varying sizes. They may appear nodular, plaque-like, or granular, are quite mobile, and have no adhesion to surrounding tissues. The size and characteristics of the lumps commonly change with the menstrual cycle and emotional fluctuations, and they tend to grow slowly, predominantly affecting young and middle-aged women. In contrast, breast cancer lumps are generally harder, usually unilateral and solitary. These lumps may be round, oval, or irregular in shape, can grow quite large, have limited mobility, and tend to adhere to the skin and surrounding tissues. The lumps are not related to the menstrual cycle or emotional changes, can increase in size rapidly over a short period, and are more commonly seen in middle-aged and older women. Sometimes breast cancer can be confused with breast hyperplasia, necessitating a hospital visit for examination and diagnostic differentiation by a doctor.

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Written by Zhang Chao Jie
Breast Surgery
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Does breast cancer require chemotherapy?

Not all breast cancer requires chemotherapy, which is just one method in the comprehensive treatment of breast cancer. Comprehensive treatment for breast cancer includes surgery, chemotherapy, radiotherapy, endocrine therapy, biological targeted therapy, and also traditional Chinese medicine treatment. Chemotherapy, in particular, can be described as a double-edged sword that kills both cancerous and normal cells. If the breast cancer is in an early stage, especially if the genetic typing is favorable, there might be an opportunity to forego chemotherapy. However, unfortunately, as of now, a significant portion of breast cancer cases still require chemotherapy. Therefore, it is necessary to communicate with professional doctors and analyze each specific case individually; one cannot generalize the treatment.