Is Parkinson's disease hereditary?

Written by Zhang Hui
Neurology
Updated on September 03, 2024
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Parkinson's disease is mainly divided into two types. One type is familial Parkinson's disease, which definitely has a clear genetic predisposition. This disease is caused by mutations in some genes that lead to disruptions in some internal environments and the accumulation of abnormal proteins, eventually causing the death of neurons. Since the disease is caused by genetic mutations, there is definitely a certain genetic predisposition, and reproductive counseling is necessary to prevent the birth of offspring with Parkinson's disease. Moreover, most cases of Parkinson's disease are sporadic, and these diseases may be related to acquired factors, such as long-term mental stress, excessive pressure, brain trauma, or cerebrovascular diseases in patients, which can all lead to Parkinson's disease. This type of disease is definitely not inherited, so there is no need to worry too much.

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Written by Zhou Yan
Geriatrics
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What is the best way to exercise for Parkinson's disease?

Patients with Parkinson's disease should undergo comprehensive treatment and full management. Drug treatment is the core treatment plan, but it is also necessary to include physical rehabilitation and psychological therapy. For physical therapy, patients should be encouraged to exercise more, as this can help improve symptoms and slow the progression of the disease. The type and intensity of exercise should be chosen based on the patient's motor symptoms. Tai Chi, jogging, brisk walking, and aerobics are all suitable forms of exercise, and it is advisable to exercise four times a week, with each session lasting about 30 minutes. Evidence has shown that Tai Chi can improve patients' balance disorders, and long-term persistence in exercise can help improve their quality of life.

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Written by Zhang Hui
Neurology
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What is needed to diagnose Parkinson's disease?

The definitive diagnosis of Parkinson's disease primarily relies on the patient's medical history, clinical manifestations, and a thorough physical examination by a neurologist. If the onset of the disease is very slow, presenting with symptoms such as bradykinesia and tremors, and the neurologist observes heightened muscle tone and slow movements during the examination, a high suspicion of this disease is warranted. Additionally, certain auxiliary tests are necessary, commonly including: First, testing the patient's sense of smell is crucial, as a reduced sense of smell is very important in diagnosing Parkinson's disease. Second, some brain MRI scans are needed mainly to exclude some secondary Parkinson's syndromes. Third, a brain PET-CT scan can be performed to examine the functionality of the striatum. Furthermore, an ultrasound of the substantia nigra in the midbrain can also be conducted, which holds significant value in assisting the diagnosis.

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Written by Zhou Yan
Geriatrics
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Parkinson's disease skin symptoms

In Parkinson's disease, there are two main types of clinical manifestations. One is motor symptoms associated with damage to the dopaminergic system, and the other is non-motor symptoms related to damage of non-dopaminergic systems. The non-motor symptoms include olfactory dysfunction, sleep disorders, mood disorders, as well as cognitive and psychiatric behavioral disturbances. Additionally, there are dysfunctions of the autonomic nervous system, which manifest in the gastrointestinal tract mainly as constipation, and in the urinary system as urinary incontinence, urinary frequency, urinary retention, and sexual dysfunction. There also occurs orthostatic hypotension, along with changes in the skin. Some patients may experience abnormal increases or decreases in sweating and abnormal secretion of sebum in the facial area, which are specific skin symptoms of Parkinson's disease.

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Written by Zhang Hui
Neurology
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What to do about constipation in Parkinson's disease?

Among Parkinson's disease patients, constipation is a very common clinical symptom. In fact, many patients have experienced constipation for many years before the onset of Parkinson's disease symptoms, mainly due to the impact on some autonomic nerves in the intestines. For Parkinson's patients experiencing constipation, the main suggestions are: First, be sure to drink plenty of water. Drinking enough water can sufficiently lubricate the intestines and facilitate smoother bowel movements. Second, be sure to eat plenty of fresh vegetables and fruits. Vegetables and fruits are rich in vitamin C and can promote gastrointestinal motility. Additionally, it is recommended for patients to eat more bananas, as bananas have an evident laxative effect. Also, eat less of certain foods that can dry out the stool, such as sweet potatoes and chestnuts. If necessary, patients can be given laxative medications, and if bowel movements are extremely difficult, enemas can also be administered.

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Written by Zhang Hui
Neurology
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How is Parkinson's disease cured?

The treatment of Parkinson's disease involves various aspects, and the principle of its treatment is not to aim for complete effectiveness but for prolonged and sustainable management. It is important not to be tempted by temporary symptom improvement and miss out on a sequential treatment that could last for many years. The treatment of Parkinson’s disease mainly includes the following aspects: The first aspect is the care of daily life, which is very important. It is necessary to install some very convenient facilities at home for the patient, such as installing some handles, using some higher chairs, etc., all of which help to improve the quality of life for the patient. The second aspect is pharmacotherapy. According to the patient's condition, appropriate anti-Parkinson's medication is selected, mainly including dopamine receptor agonists, COMT inhibitors, and some levodopa preparations. Adjusting medication is very complex and must be conducted under the guidance of a professional neurologist. In addition, attention should also be paid to the treatment of non-motor symptoms, such as treating the patient's constipation, depression, etc.