Is Parkinson's disease hereditary?

Written by Zhang Hui

Neurology

Updated on May 26, 2025

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A small portion of Parkinson's disease has a genetic predisposition. According to research statistics, about 5% to 10% of Parkinson’s disease cases are familial, caused by certain gene mutations leading to neurodegeneration. This part of the disease does have a genetic predisposition. However, it does not mean that if the parents have the disease, the child will definitely inherit it; environmental factors are also related. Most cases of Parkinson’s disease do not have a genetic predisposition and are sporadic, possibly related to cerebral ischemia, hypoxia, stress, mitochondrial dysfunction, and long-term exposure to certain toxins. These aspects are definitely not hereditary. Parkinson's disease is a neurodegenerative disorder that can cause symptoms such as bradykinesia, increased muscle tone, and unstable posture. It is important to seek medical treatment promptly.

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Written by Zhang Hui

Neurology

1min 4sec

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What to do about constipation in Parkinson's disease?

Among Parkinson's disease patients, constipation is a very common clinical symptom. In fact, many patients have experienced constipation for many years before the onset of Parkinson's disease symptoms, mainly due to the impact on some autonomic nerves in the intestines. For Parkinson's patients experiencing constipation, the main suggestions are: First, be sure to drink plenty of water. Drinking enough water can sufficiently lubricate the intestines and facilitate smoother bowel movements. Second, be sure to eat plenty of fresh vegetables and fruits. Vegetables and fruits are rich in vitamin C and can promote gastrointestinal motility. Additionally, it is recommended for patients to eat more bananas, as bananas have an evident laxative effect. Also, eat less of certain foods that can dry out the stool, such as sweet potatoes and chestnuts. If necessary, patients can be given laxative medications, and if bowel movements are extremely difficult, enemas can also be administered.

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Written by Zhang Hui

Neurology

1min

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Can Parkinson's disease be cured?

Firstly, it must be noted that Parkinson's disease is a neurodegenerative disease which currently cannot be cured. Although Parkinson's disease cannot be cured, there are many methods available to slow the progression of the disease and improve the quality of life for patients. Patients must take medication regularly under the guidance of a doctor. The treatment methods for Parkinson's disease mainly include: First, patients should strengthen their functional training and engage in as much physical activity and exercise as possible, which can help in treating the disease. Second, regular medication is necessary, mainly referring to drugs used for treating Parkinson's disease. These include dopamine receptor agonists, anticholinergic drugs, and Levodopa preparations, all of which can have good effects, but these medications also have certain side effects and require regular follow-up visits at outpatient clinics. (Specific medications should be taken under the guidance of a physician.)

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Written by Zhang Hui

Neurology

54sec

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Causes of Parkinson's Disease

The cause of Parkinson's disease is mainly due to a part of the brain called the brainstem, which has some black moles and clusters containing a large number of neurons that can produce dopamine. The death of these neurons in the substantia nigra of the midbrain, caused by various factors, leads to Parkinson's disease. This results in noticeable slowness of movement in the limbs, muscle rigidity, as well as tremors, and unstable walking and other clinical manifestations. The causes of the death of dopaminergic neurons in the substantia nigra include genetic factors. Additionally, age is the biggest cause of the disease. Furthermore, dysfunctions in mitochondrial function, ischemia and hypoxia in the midbrain, certain traumas, and the use of drugs that deplete dopamine can all potentially cause Parkinson's disease.

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Written by Zhang Hui

Neurology

56sec

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Is Parkinson's disease hereditary?

Parkinson's disease is mainly divided into two types. One type is familial Parkinson's disease, which definitely has a clear genetic predisposition. This disease is caused by mutations in some genes that lead to disruptions in some internal environments and the accumulation of abnormal proteins, eventually causing the death of neurons. Since the disease is caused by genetic mutations, there is definitely a certain genetic predisposition, and reproductive counseling is necessary to prevent the birth of offspring with Parkinson's disease. Moreover, most cases of Parkinson's disease are sporadic, and these diseases may be related to acquired factors, such as long-term mental stress, excessive pressure, brain trauma, or cerebrovascular diseases in patients, which can all lead to Parkinson's disease. This type of disease is definitely not inherited, so there is no need to worry too much.

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Written by Zhang Hui

Neurology

1min 2sec

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What is needed to diagnose Parkinson's disease?

The definitive diagnosis of Parkinson's disease primarily relies on the patient's medical history, clinical manifestations, and a thorough physical examination by a neurologist. If the onset of the disease is very slow, presenting with symptoms such as bradykinesia and tremors, and the neurologist observes heightened muscle tone and slow movements during the examination, a high suspicion of this disease is warranted. Additionally, certain auxiliary tests are necessary, commonly including: First, testing the patient's sense of smell is crucial, as a reduced sense of smell is very important in diagnosing Parkinson's disease. Second, some brain MRI scans are needed mainly to exclude some secondary Parkinson's syndromes. Third, a brain PET-CT scan can be performed to examine the functionality of the striatum. Furthermore, an ultrasound of the substantia nigra in the midbrain can also be conducted, which holds significant value in assisting the diagnosis.