Atrial septal defect is a relatively common congenital heart disease in clinical practice. Minimally invasive interventional treatment can effectively address atrial septal defects and generally leaves no surgical scars. The complications of atrial septal defects can be analyzed from the following aspects: First, puncture complications. Atrial septal defects require the puncture of the femoral vein. A small number of patients may experience complications such as arteriovenous fistula, pseudoaneurysm, or hematoma at the puncture site. Generally, these complications are not serious and do not endanger the patient's life. Second, complications from dislodged occlusion devices. If the occlusion device becomes dislodged, it can lead to serious complications, including obstruction of the relevant blood vessels. Third, hemolytic reactions. A small number of patients may develop hemolytic reactions to the occlusion device. Such complications are also quite serious; however, they are very rare in clinical practice and do not require excessive concern.