Can IgA nephropathy be cured?

Written by Zhou Qi
Nephrology
Updated on September 09, 2024
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IgA nephropathy cannot be completely cured. IgA nephropathy is a type of chronic glomerulonephritis and is a chronic disease. Currently, it is incurable in medical practice. However, many patients have only mild symptoms, such as mild hematuria, proteinuria, and minor kidney damage, and timely long-term management of the disease usually does not lead to severe consequences. Some patients, on the other hand, have relatively severe conditions and require treatment with steroid medications. Most of these patients can achieve relatively good treatment outcomes and ultimately avoid severe kidney failure. However, a very small number of patients may eventually experience significant proteinuria and even severe renal failure.

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Written by Li Liu Sheng
Nephrology
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Is IgA nephropathy grade 3 serious?

IgA nephropathy is divided into five stages pathologically, with stage three being the focal proliferative type. The higher the stage, the more severe the condition of IgA nephropathy. Stage three is in the early to middle phase, where generally the condition of the patients is comparatively good, and rarely worsens to uremia, belonging to the low-risk group. Clinically, patients with stage three IgA nephropathy often exhibit repeated occurrences of gross hematuria or persistent microscopic hematuria. Some patients may also experience varying degrees of increased urinary protein. Patients with this stage of IgA nephropathy rarely suffer from hypertension or renal insufficiency, but it is essential in daily life to avoid nephrotoxic drugs, prevent infections, seek medical attention promptly upon infection, and regularly follow up on routine urine and renal function changes. If the condition tends to worsen, active treatment should be pursued.

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Written by Zhou Qi
Nephrology
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IgA nephropathy is a kidney disease.

In medical terms, there is a condition named IgA nephropathy. IgA is actually a type of immunoglobulin. The function of immunoglobulins is to bind with antigens, which then induces an inflammatory response. For example, when bacteria enter the human body, the combination of IgA with the bacteria guides the body's immune system to target and attack the bacteria, which is a normal scenario. This IgA immunoglobulin acts as a mediator in the immune response. Due to some defect, this substance accumulates in the glomeruli. Its deposition in the glomerular capillaries can trigger inflammation in these blood vessels, leading to IgA nephropathy. This results in proliferation of glomerular mesangial cells, deposition in the mesangial matrix, causing blood and protein in the urine, and even leading to renal failure.

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Written by Hu Lin
Nephrology
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IgA kidney disease's etiology

IgA nephropathy can be divided into primary and secondary IgA nephropathy. Secondary IgA nephropathy includes, for example, lupus nephritis, allergic purpura nephritis, liver disease-related kidney damage, rheumatoid arthritis kidney damage, and so on. The etiology of primary IgA nephropathy is mainly due to the deposition of a type of immunoglobulin, IgA, in the mesangial area of the glomeruli, leading to a series of immune responses, which in turn cause inflammatory damage, resulting in a chronic glomerulonephritis. This form of IgA nephropathy is mainly related to mucosal immune defense, meaning it is linked to certain infectious factors. Additionally, some patients have high reactivity of their mucosa to certain food antigens, which leads to a series of immune-mediated inflammatory responses.

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Written by Li Liu Sheng
Nephrology
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What will happen if someone with IgA nephropathy stays up late?

IgA nephropathy is a very common glomerular disease in clinical settings and is one of the main causes of uremia. IgA nephropathy is most commonly seen in adolescents, particularly in males. The cause of IgA nephropathy is currently unclear, but the clinical manifestations of patients with IgA nephropathy are numerous and vary in severity. For patients with milder IgA nephropathy, it is important to maintain a healthy lifestyle, avoid staying up late, overworking, and infections. Frequently staying up late can aggravate the condition, leading to significant proteinuria and even worsening kidney function. Therefore, it is crucial for patients with IgA nephropathy to regularly monitor their urinalysis, kidney function, and blood pressure, maintain a regular lifestyle, and avoid various adverse lifestyle impacts. Of course, once the condition worsens, it is important to seek medical attention promptly and pursue active treatment.

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Written by Li Liu Sheng
Nephrology
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Can IgA nephropathy hematuria heal itself?

Hematuria is the most common clinical manifestation of IgA nephropathy. As IgA nephropathy is a chronic disease and not self-healing, the hematuria associated with it does not resolve on its own and will repeatedly occur or exacerbate. Typically, patients with IgA nephropathy exhibit microscopic hematuria when the condition is stable. However, gross hematuria may appear during physical exertion or respiratory infections, such as pharyngitis. In addition, IgA nephropathy patients also show increased urinary protein and can experience elevated blood pressure. Back pain is also a common clinical manifestation in patients with IgA nephropathy, so there is no need to be overly concerned about the presence of blood in the urine.