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Cui Fang Bo
Oncology
About me
Specializing in the clinical and scientific research of anticancer drugs, especially targeted therapies. Serving as the principal investigator, leading a project funded by the National Natural Science Foundation of China. As the first author, published multiple academic papers, including 6 English-language papers indexed in SCI, with the highest impact factor being 6.49.
Proficient in diseases
Treatment with anticancer drugs, especially the use of targeted therapy for tumors.
Voices
Has rectal cancer progressed to the advanced stage with vomiting?
Patients with rectal cancer who experience vomiting do not necessarily indicate that their condition has reached an advanced stage; the situation needs to be differentiated and treated accordingly. If nausea and vomiting are due to the gastrointestinal side effects of antitumor treatments such as chemotherapy and radiotherapy, it is unrelated to the severity of rectal cancer. Appropriate antiemetic treatment can provide significant relief. If a rectal cancer patient experiences projectile vomiting due to brain metastases, which lead to an increase in intracranial pressure, it indicates that the disease has progressed to an advanced stage. Some rectal cancer patients may also experience vomiting due to gastrointestinal obstruction caused by the tumor, accompanied by cessation of bowel movements and gas, which are also signs of advanced disease.
Melanoma stage IV is the fourth stage.
Melanoma stage IV refers to the fourth stage of melanoma, where IV represents the Roman numeral for 4. Stage IV melanoma means that the melanoma is no longer confined to the local lesion but has metastasized to distant organs. The most common locations for melanoma include the skin and mucous membranes, with typical metastatic sites including the lungs, brain, liver, etc. Once diagnosed as stage IV, there are no indications for surgical treatment. Treatment primarily involves a comprehensive approach combining chemotherapy, radiotherapy, targeted therapy, and immunotherapy.
What are the early symptoms of thyroid cancer?
The most common clinical symptom of thyroid cancer in its early stages is an abnormal lump in the neck. Additionally, some patients may experience symptoms related to abnormal thyroid function. Thyroid cancer is currently a malignant tumor with a relatively high incidence rate globally and in China. There are four pathological types of thyroid cancer: papillary carcinoma, follicular carcinoma, undifferentiated carcinoma, and medullary carcinoma. Among these, papillary carcinoma is the most common and has the best prognosis. For patients presenting with an abnormal neck lump and thyroid function abnormalities, the diagnosis of thyroid cancer should be considered. Diagnosis can be confirmed through tissue obtained by biopsy or surgical excision for pathological examination. For patients with confirmed diagnoses of thyroid cancer, surgery is the preferred treatment method.
Stage IV melanoma is what stage?
Melanoma stage IV is stage 4, where IV is the Roman numeral for 4. Stage IV melanoma means that the melanoma is no longer confined to the site of origin and has metastasized to distant organs. Melanoma commonly originates in the skin and mucous membranes, with the most common sites of metastasis being the lymph nodes and lungs. Once melanoma reaches stage 4, the opportunity for curative surgery is lost. Treatment primarily involves immunotherapy, targeted molecular therapy, etc., and is incurable.
How does an ultrasound show early-stage liver cancer?
Liver cancer can be detected in its early stages through Doppler ultrasound examination, which may reveal single or multiple abnormal masses within the liver. These masses often vary in size and have irregular edges, with blood flow signals inside. If liver cancer is suspected from the Doppler ultrasound, further examination with an abdominal CT or MRI can provide more detailed information about the lesions to aid in judgment. A definitive diagnosis relies on surgical removal or percutaneous liver biopsy to obtain local tissue for pathological confirmation. Patients with early-stage diagnosed liver cancer should undergo surgical treatment as soon as possible, and those who can have radical resection generally have a better prognosis.
Is laser treatment or surgical removal better for melanoma?
Regarding whether laser treatment or surgical excision is better for melanoma, the answer is clear: surgical excision is better. Melanoma originates from melanocytes and is not limited to one layer of the skin. Therefore, for melanoma of the skin, the infiltration depth can sometimes be profound, reaching the dermis layer. Laser treatment sometimes only covers a superficial depth, which cannot achieve complete removal. Surgical excision can completely remove deeper infiltrative parts of the melanoma, and after the excision, complete tissues can be obtained for pathological examination, which helps in staging after the surgery and guides treatment post-surgery. Laser treatment does not offer these benefits. Therefore, current guidelines recommend surgical excision for the treatment of melanoma and do not recommend laser treatment.
What should be done after the complete removal of colon cancer?
After surgical removal of colon cancer, the postoperative treatment strategy should be determined based on the precise staging of the cancer according to the surgical pathology. If the colon cancer has invaded the mucosal layer and the submucosal layer, or the muscular layer, it is staged as stage I; postoperative adjuvant chemotherapy is not required, and regular follow-up is sufficient. If the colon cancer reaches stage II or III, postoperative adjuvant chemotherapy is needed to reduce the risk of postoperative recurrence and metastasis. Stage IV colon cancer does not fall under the aforementioned conditions of clean removal of the cancer.
What is the likelihood of metastasis for colon cancer with a certain Ki-67 index?
Currently, the Ki67 index in colon cancer cannot be used as a predictive factor for metastasis. Ki67 reflects the proliferation index of the tumor and is related to the malignancy level of the tumor, but it is not possible to judge the risk of subsequent metastasis based on the Ki67 value. The factors that can be used to assess the risk of postoperative metastasis in colon cancer mainly include the depth of local invasion of the colon cancer, whether there is lymph node metastasis, and the presence of certain specific gene mutations. The deeper the invasion, the higher the risk of metastasis. Patients with lymph node metastasis have a higher risk of distant recurrence and metastasis compared to those without detected lymph node metastasis.
What are the abnormalities in blood indicators for pancreatic cancer?
Blood markers for pancreatic cancer often show multiple abnormalities. Pancreatic cancer itself can lead to an increase in related tumor markers. The two most common markers are carcinoembryonic antigen and carbohydrate antigen 19-9, especially carbohydrate antigen 19-9, which has a certain specificity. If pancreatic cancer progresses further, leading to compression of the biliary system, corresponding jaundice indicators can increase. This includes an increase in total bilirubin and direct bilirubin, as well as alkaline phosphatase and gamma-GTP. The most common metastasis site for pancreatic cancer is the liver, and after liver metastasis occurs, corresponding liver transaminases can increase.
Is the alpha-fetoprotein high in the early stage of liver cancer?
Patients with liver cancer may not necessarily have elevated carcinoembryonic antigen (CEA) levels in the early stages. CEA, a commonly used tumor marker, tends to increase in various types of malignancies. However, an elevation in CEA is not necessarily linked to the occurrence of malignant tumors. Many patients with early-stage tumors, including liver cancer, may not have elevated CEA levels at diagnosis. Conversely, elevated CEA levels in some patients may be due to benign conditions and not necessarily indicate malignancy. Therefore, it is unreasonable to determine the presence of liver cancer solely based on the elevation of CEA.