Cor pulmonale refers to the disease characterized by increased pulmonary vascular resistance due to pathological changes in the bronchi, lung tissue, thorax, or pulmonary vessels, leading to pulmonary arterial pressure and subsequently causing changes in the structure and function of the right ventricle. When cor pulmonale occurs, treatment is generally divided into the acute exacerbation phase where active control of infections, clearing of the airways, improvement of respiratory function, correction of hypoxia and carbon dioxide retention, control of respiratory failure and acute heart failure, and management of complications are emphasized. During the chronic remission phase, the goal is to enhance the patient's immune function, eliminate triggering factors, reduce or avoid the occurrence of acute exacerbations, and partially or fully restore cardiopulmonary function.