Breast lobular hyperplasia can worsen with mood because it is related to elevated estrogen levels caused by endocrine disorders. External living conditions, work and life circumstances, interpersonal relationships, and various other stresses can cause neuropsychiatric factors, all of which can change the internal environment of the body. This, in turn, affects the function of the endocrine system, leading to abnormal secretion of one or several hormones. During the menstrual cycle, breast receptors and internal hormone levels change periodically. When the proportion of hormones in the body becomes unbalanced, an increase in estrogen levels and a decrease in progesterone secretion can lead to incomplete regression of breast hyperplasia after its increase, causing the exacerbation of breast hyperplasia.